Effects of aging on $$T_{1}$$ T 1 , $$T_{2}^{*}$$ T 2 ∗ , and QSM MRI values in the subcortex

Effects of aging on $$T_{1}$$ T 1 , $$T_{2}^{*}$$ T 2 ∗ , and QSM MRI values... The aging brain undergoes several anatomical changes that can be measured with Magnetic Resonance Imaging (MRI). Early studies using lower field strengths have assessed changes in tissue properties mainly qualitatively, using $$T_{1}$$ T 1 - or $$T_{2}^{*}$$ T 2 ∗ - weighted images to provide image contrast. With the development of higher field strengths (7 T and above) and more advanced MRI contrasts, quantitative measures can be acquired even of small subcortical structures. This study investigates volumetric, spatial, and quantitative MRI parameter changes associated with healthy aging in a range of subcortical nuclei, including the basal ganglia, red nucleus, and the periaqueductal grey. The results show that aging has a heterogenous effects across regions. Across the subcortical areas an increase of $$T_{1}$$ T 1 values is observed, most likely indicating a loss of myelin. Only for a number of areas, a decrease of $$T_{2}^{*}$$ T 2 ∗ and increase of QSM is found, indicating an increase of iron. Aging also results in a location shift for a number of structures indicating the need for visualization of the anatomy of individual brains. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Structure and Function Springer Journals

Effects of aging on $$T_{1}$$ T 1 , $$T_{2}^{*}$$ T 2 ∗ , and QSM MRI values in the subcortex

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by The Author(s)
Subject
Biomedicine; Neurosciences; Cell Biology; Neurology
ISSN
1863-2653
eISSN
1863-2661
D.O.I.
10.1007/s00429-016-1352-4
Publisher site
See Article on Publisher Site

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