Effects of a hemagglutinin D222G substitution on the pathogenicity of 2009 influenza A (H1N1) virus in mice

Effects of a hemagglutinin D222G substitution on the pathogenicity of 2009 influenza A (H1N1)... The surface glycoprotein hemagglutinin (HA) of influenza virus initiates the infection process by binding to sialic acid receptors on upper respiratory cells in the host. In contrast to avian influenza viruses, which bind to sialic acids connected by an α2-3 linkage to the penultimate galactose, human influenza viruses prefer sialic acids with an α2-6 linkage. Recently, there have been multiple cases of severe human infections associated with an HA D222G mutant influenza virus. In this study, we have investigated the pathogenic effects of the HA D222G substitution in a 2009 pandemic H1N1 virus in mice. Compared with the A/Korea/01/2009 (K/09) virus, the HA D222G mutant showed reduced growth in cells and reduced binding avidity to human and turkey red blood cells. In a BALB/c mouse infection model, infection with the HA D222G mutant virus resulted in less body weight loss when compared to the parental K/09 virus. Altogether, our data suggest that the HA D222G substitution in the K/09 virus might be deleterious to viral fitness. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Effects of a hemagglutinin D222G substitution on the pathogenicity of 2009 influenza A (H1N1) virus in mice

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Publisher
Springer Vienna
Copyright
Copyright © 2014 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-014-2104-5
Publisher site
See Article on Publisher Site

References

  • Predicting the evolution of human influenza A
    Bush, RM; Bender, CA; Subbarao, K; Cox, NJ; Fitch, WM
  • Haemagglutinin D222G mutation found in a fatal case of pandemic (H1N1) flu in Tunisia
    Moussi, A; Ledesma, J; Ben Hadj Kacem, MA; Pozo, F; Cuevas, MT; Hamdoun, M; Casas, I; Perez-Brena, P; Slim, A
  • Molecular mechanisms of interspecies transmission and pathogenicity of influenza viruses: lessons from the 2009 pandemic
    Klenk, HD; Garten, W; Matrosovich, M
  • Detection of haemagglutinin D222 polymorphisms in influenza A(H1N1)pdm09-infected patients by ultra-deep pyrosequencing
    Selleri, M; Piralla, A; Rozera, G; Giombini, E; Bartolini, B; Abbate, I; Campanini, G; Rovida, F; Dossena, L; Capobianchi, MR; Baldanti, F

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