Effect of wine on carotid atherosclerosis in type 2 diabetes: a 2-year randomized controlled trial

Effect of wine on carotid atherosclerosis in type 2 diabetes: a 2-year randomized controlled trial Background/Objectives The progression of carotid-plaque volume in patients with type 2 diabetes is common. Previous observational studies showed an association between moderate alcohol and reduced risk of coronary disease. We examined whether consuming moderate wine affects the progression of carotid atherosclerosis. Subjects/Methods In the CASCADE (CArdiovaSCulAr Diabetes and Ethanol), a 2-year randomized controlled trial, we randomized abstainers with type 2 diabetes were to drink 150 ml of either red wine, white wine, or water, provided for 2 years. In addition, groups were guided to maintain a Mediterranean diet. We followed 2-year changes in carotid total plaque volume (carotid-TPV) and carotid vessel wall volume (carotid-VWV), using three-dimensional ultrasound. Results Carotid images were available from 174 of the 224 CASCADE participants (67% men; age = 59 yr; HbA1C = 6.8%). Forty-five percent had detectable plaque at baseline. After 2 years, no significant progression in carotid-TPV was 3 3 3 observed (water, −1.4 (17.0) mm ,CI (−2.7, 5.5), white-wine, −1.2 (16.9) mm ,CI (−3.8, 6.2), red wine, −1.3 (17.6) mm , CI (−3.4, 6.0; p = 0.9 between groups)). In post hoc analysis, we divided the 78 participants with detectable baseline carotid plaque into tertiles. Those with the higher baseline plaque burden, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Clinical Nutrition Springer Journals

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/lp/springer_journal/effect-of-wine-on-carotid-atherosclerosis-in-type-2-diabetes-a-2-year-4fAfINBelC
Publisher
Nature Publishing Group UK
Copyright
Copyright © 2018 by Macmillan Publishers Limited, part of Springer Nature
Subject
Medicine & Public Health; Medicine/Public Health, general; Public Health; Epidemiology; Internal Medicine; Clinical Nutrition; Metabolic Diseases
ISSN
0954-3007
eISSN
1476-5640
D.O.I.
10.1038/s41430-018-0091-4
Publisher site
See Article on Publisher Site

Abstract

Background/Objectives The progression of carotid-plaque volume in patients with type 2 diabetes is common. Previous observational studies showed an association between moderate alcohol and reduced risk of coronary disease. We examined whether consuming moderate wine affects the progression of carotid atherosclerosis. Subjects/Methods In the CASCADE (CArdiovaSCulAr Diabetes and Ethanol), a 2-year randomized controlled trial, we randomized abstainers with type 2 diabetes were to drink 150 ml of either red wine, white wine, or water, provided for 2 years. In addition, groups were guided to maintain a Mediterranean diet. We followed 2-year changes in carotid total plaque volume (carotid-TPV) and carotid vessel wall volume (carotid-VWV), using three-dimensional ultrasound. Results Carotid images were available from 174 of the 224 CASCADE participants (67% men; age = 59 yr; HbA1C = 6.8%). Forty-five percent had detectable plaque at baseline. After 2 years, no significant progression in carotid-TPV was 3 3 3 observed (water, −1.4 (17.0) mm ,CI (−2.7, 5.5), white-wine, −1.2 (16.9) mm ,CI (−3.8, 6.2), red wine, −1.3 (17.6) mm , CI (−3.4, 6.0; p = 0.9 between groups)). In post hoc analysis, we divided the 78 participants with detectable baseline carotid plaque into tertiles. Those with the higher baseline plaque burden,

Journal

European Journal of Clinical NutritionSpringer Journals

Published: Jan 29, 2018

References

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