Background/Objectives The progression of carotid-plaque volume in patients with type 2 diabetes is common. Previous observational studies showed an association between moderate alcohol and reduced risk of coronary disease. We examined whether consuming moderate wine affects the progression of carotid atherosclerosis. Subjects/Methods In the CASCADE (CArdiovaSCulAr Diabetes and Ethanol), a 2-year randomized controlled trial, we randomized abstainers with type 2 diabetes were to drink 150 ml of either red wine, white wine, or water, provided for 2 years. In addition, groups were guided to maintain a Mediterranean diet. We followed 2-year changes in carotid total plaque volume (carotid-TPV) and carotid vessel wall volume (carotid-VWV), using three-dimensional ultrasound. Results Carotid images were available from 174 of the 224 CASCADE participants (67% men; age = 59 yr; HbA1C = 6.8%). Forty-ﬁve percent had detectable plaque at baseline. After 2 years, no signiﬁcant progression in carotid-TPV was 3 3 3 observed (water, −1.4 (17.0) mm ,CI (−2.7, 5.5), white-wine, −1.2 (16.9) mm ,CI (−3.8, 6.2), red wine, −1.3 (17.6) mm , CI (−3.4, 6.0; p = 0.9 between groups)). In post hoc analysis, we divided the 78 participants with detectable baseline carotid plaque into tertiles. Those with the higher baseline plaque burden,
European Journal of Clinical Nutrition – Springer Journals
Published: Jan 29, 2018
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