Effect of Technically Relevant X-Ray Doses on the Structure and Function of Alcohol Dehydrogenase and Hen Egg-White Lysozyme

Effect of Technically Relevant X-Ray Doses on the Structure and Function of Alcohol Dehydrogenase... Pharm Res (2018) 35: 135 https://doi.org/10.1007/s11095-018-2417-2 RESEARCH PAPER Effect of Technically Relevant X-Ray Doses on the Structure and Function of Alcohol Dehydrogenase and Hen Egg-White Lysozyme 1 1 1 1 Lisa-Marie Schaden & Miriam Wimmer-Teubenbacher & Johannes Poms & Peter Laggner & 2 1 1 1 Karl Lohner & Stephan Sacher & Johannes G. Khinast & Sharareh Salar-Behzadi Received: 13 November 2017 /Accepted: 22 April 2018 /Published online: 7 May 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018 . . KEY WORDS Alcohol dehydrogenase Heat stress Hen ABSTRACT . . Purpose The effect of different irradiation doses on the struc- egg-white lysozyme Protein structure X-ray ture and activity of lyophilized powders of Hen Egg-White Lysozyme (HEWL) and alcohol dehydrogenase (ADH) was investigated using these substances as models for robust and ABBREVIATIONS sensitive proteins, respectively. Three doses were selected to AABB American Association of Blood Banks cover the ranges of radio-sterilization (25kGy), treatment of ADH Alcohol dehydrogenase blood products (25Gy) and annual background radiation dose ANOVA Analysis of variance (approximately 2mGy). The results offer an initial screening of BCSH British Committee for Standard in Haematology different irradiation doses and support the development of X- β- β-Nicotinamide adenine http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmaceutical Research Springer Journals

Effect of Technically Relevant X-Ray Doses on the Structure and Function of Alcohol Dehydrogenase and Hen Egg-White Lysozyme

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Biomedicine; Pharmacology/Toxicology; Pharmacy; Biochemistry, general; Medical Law; Biomedical Engineering
ISSN
0724-8741
eISSN
1573-904X
D.O.I.
10.1007/s11095-018-2417-2
Publisher site
See Article on Publisher Site

Abstract

Pharm Res (2018) 35: 135 https://doi.org/10.1007/s11095-018-2417-2 RESEARCH PAPER Effect of Technically Relevant X-Ray Doses on the Structure and Function of Alcohol Dehydrogenase and Hen Egg-White Lysozyme 1 1 1 1 Lisa-Marie Schaden & Miriam Wimmer-Teubenbacher & Johannes Poms & Peter Laggner & 2 1 1 1 Karl Lohner & Stephan Sacher & Johannes G. Khinast & Sharareh Salar-Behzadi Received: 13 November 2017 /Accepted: 22 April 2018 /Published online: 7 May 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018 . . KEY WORDS Alcohol dehydrogenase Heat stress Hen ABSTRACT . . Purpose The effect of different irradiation doses on the struc- egg-white lysozyme Protein structure X-ray ture and activity of lyophilized powders of Hen Egg-White Lysozyme (HEWL) and alcohol dehydrogenase (ADH) was investigated using these substances as models for robust and ABBREVIATIONS sensitive proteins, respectively. Three doses were selected to AABB American Association of Blood Banks cover the ranges of radio-sterilization (25kGy), treatment of ADH Alcohol dehydrogenase blood products (25Gy) and annual background radiation dose ANOVA Analysis of variance (approximately 2mGy). The results offer an initial screening of BCSH British Committee for Standard in Haematology different irradiation doses and support the development of X- β- β-Nicotinamide adenine

Journal

Pharmaceutical ResearchSpringer Journals

Published: May 7, 2018

References

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