Effect of recent spinal cord injury on the OPG/RANKL system and its relationship with bone loss and the response to denosumab therapy

Effect of recent spinal cord injury on the OPG/RANKL system and its relationship with bone loss... Summary There is marked bone loss after spinal cord injury prospectively included. Serum OPG and RANKL levels, bone (SCI); however, its pathogenesis and clinical management re- turnover markers (PINP, bone ALP, CTX), and bone mineral main unclear. The increased circulating levels of receptor ac- density (BMD) were assessed at baseline, at 6 months of fol- tivator of nuclear factor kB ligand (RANKL) associated with low-up, prior to initiating denosumab, and 6 months after treat- bone loss shortly after SCI and the prevention of bone loss ment. The results were compared with a healthy control group. Results At baseline, SCI patients showed higher RANKL with denosumab treatment suggest a contributory role of RANKL in SCI-induced osteoporosis. levels vs. controls which were correlated with days-since-SCI Introduction Bone turnover and bone loss are markedly and total hip BMD loss at 6 months. OPG levels were similar to increased shortly after SCI. However, the pathogenesis controls at baseline. After denosumab treatment, OPG showed and clinical management of this process remain unclear, no changes, whereas RANKL levels became undetectable in especially the role of the osteoprotegerin (OPG)/RANKL 67% of patients. Patients with undetectable RANKL during system in this disorder. The aim of this study http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Osteoporosis International Springer Journals

Effect of recent spinal cord injury on the OPG/RANKL system and its relationship with bone loss and the response to denosumab therapy

Loading next page...
Springer London
Copyright © 2017 by International Osteoporosis Foundation and National Osteoporosis Foundation
Medicine & Public Health; Orthopedics; Endocrinology; Rheumatology
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial