Pharm Res (2018) 35:70 https://doi.org/10.1007/s11095-017-2332-y RESEARCH PAPER Effect of Permeation Enhancers on the Buccal Permeability of Nicotine: Ex vivo Transport Studies Complemented by MALDI MS Imaging 1 2 1 1 3 2 Eva Marxen & Liang Jin & Jette Jacobsen & Christian Janfelt & Birgitte Hyrup & Joseph A. Nicolazzo Received: 23 October 2017 /Accepted: 18 December 2017 # Springer Science+Business Media, LLC, part of Springer Nature 2018 ABSTRACT primarily diffuses via the transcellular pathway. MALDI Purpose The purpose of this study was to assess the effect of MSI was shown to complement ex vivo permeability studies several chemical permeation enhancers on the buccal perme- and to be a useful qualitative tool for visualizing drug and ability of nicotine and to image the spatial distribution of penetration enhancer distribution in buccal mucosa. nicotine in buccal mucosa with and without buccal perme- . . ation enhancers. KEY WORDS buccal mucosa mass spectrometry imaging . . Methods The impact of sodium taurodeoxycholate (STDC), nicotine permeability permeation enhancer sodium dodecyl sulphate (SDS), dimethyl sulfoxide (DMSO) 3 14 and Azone® on the permeability of [ H]-nicotine and [ C]- mannitol (a paracellular marker) across porcine buccal muco- ABBREVIATIONS sa was studied ex vivo
Pharmaceutical Research – Springer Journals
Published: Feb 21, 2018
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