Effect of N-[Imino(1-Piperidinyl)Methyl]Guanidine on Free-Radical Processes and Antioxidant-Enzyme Activity in Kidneys of Rats with Experimental Type 2 Diabetes Mellitus

Effect of N-[Imino(1-Piperidinyl)Methyl]Guanidine on Free-Radical Processes and... The effect of the synthetic biguanide derivative N-[imino(1-piperidinyl)methyl]guanidine on free-radical processes, diene conjugate levels, and superoxide-dismutase and catalase activity in kidneys of rats with experimental type 2 diabetes mellitus (DM2) was studied. It was established that administration of this compound to rats with DM2 helped to normalize the studied parameters, which may have been due to its positive regulating effect on free-radical homeostasis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmaceutical Chemistry Journal Springer Journals

Effect of N-[Imino(1-Piperidinyl)Methyl]Guanidine on Free-Radical Processes and Antioxidant-Enzyme Activity in Kidneys of Rats with Experimental Type 2 Diabetes Mellitus

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Pharmacy; Pharmacy; Pharmacology/Toxicology; Organic Chemistry
ISSN
0091-150X
eISSN
1573-9031
D.O.I.
10.1007/s11094-018-1788-3
Publisher site
See Article on Publisher Site

Abstract

The effect of the synthetic biguanide derivative N-[imino(1-piperidinyl)methyl]guanidine on free-radical processes, diene conjugate levels, and superoxide-dismutase and catalase activity in kidneys of rats with experimental type 2 diabetes mellitus (DM2) was studied. It was established that administration of this compound to rats with DM2 helped to normalize the studied parameters, which may have been due to its positive regulating effect on free-radical homeostasis.

Journal

Pharmaceutical Chemistry JournalSpringer Journals

Published: Jun 1, 2018

References

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