Effect of mutations in lawc/Trf2 gene on chromocenter formation and chromosome segregation in Drosophila melanogaster

Effect of mutations in lawc/Trf2 gene on chromocenter formation and chromosome segregation in... In Drosophila, one of the genes of the lawc/Trf2 (leg-arista-wing complex/TBP-related factor 2) complex encodes an alternative basic transcription factor homologous to the TRF2 protein in vertebrates and human and belongs to a conservative Tbp (TATA box-binding protein) gene family. In the present study, reasons for the high frequency of chromosome nondisjunction were studied among descendants of mutants from 18 lines with a decreased expression of the TRF2 protein. It was determined that the suppression of the TRF2 expression violates the development of a compact chromocenter and the correct approach of homologous chromosomes (in germinative and somatic cells). The possibility of the participation of TRF2 in the evolutionary genetically programmed process of sex-ratio meiotic drive, which is typical of a number of animal species, is discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Effect of mutations in lawc/Trf2 gene on chromocenter formation and chromosome segregation in Drosophila melanogaster

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Publisher
SP MAIK Nauka/Interperiodica
Copyright
Copyright © 2013 by Pleiades Publishing, Ltd.
Subject
Biomedicine; Human Genetics; Animal Genetics and Genomics; Microbial Genetics and Genomics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S1022795413050128
Publisher site
See Article on Publisher Site

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