Nong XG, Cheng WP, Zeng LJ. Effect of moxibustion plus Duhuo Jisheng decoction on hs-CRP, IL-1β and TNF-α levels in
middle-aged and elderly patients with knee osteoarthritis. J Acupunct Tuina Sci, 2017, 15(4): 277-280
© Shanghai Research Institute of Acupuncture and Meridian 2017︱
Special Topic Study
Effect of moxibustion plus Duhuo Jisheng decoction
on hs-CRP, IL-1β and TNF-α levels in middle-aged and
elderly patients with knee osteoarthritis
Nong Xian-gang (农贤刚), Cheng Wei-ping (程卫萍), Zeng Lin-jie (曾麟杰)
Guigang Orthopedics Hospital of Integrated Chinese and Western Medicine, Guangxi 537100, China
Objective: To observe the clinical effect of moxibustion combined with Duhuo Jisheng decoction for middle-aged and
elderly patients with knee osteoarthritis (KOA) and its impact on serum high sensitive C-reactive protein (hs-CRP),
interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) levels.
Methods: A total of 90 eligible KOA patients were randomized into an observation group (n=45) and a control group (n=45).
Cases in the observation group received moxibustion plus oral administration Duhuo Jisheng decoction, while cases in the
control group received Duhuo Jisheng decoction. Then the hs-CRP, IL-1β and TNF-α levels were examined and the clinical
effect was evaluated.
Results: Before treatment, the hs-CRP, IL-1β and TNF-α levels showed no between-group statistical differences (all
P>0.05). After 8 weeks of treatment, the hs-CRP, IL-1β and TNF-α levels all dropped significantly in both groups (P<0.01 or
P<0.05), and the treatment group showed more substantial changes than the control group (all P<0.05). The total effective
rate was 97.8% in the treatment group, versus 86.7% in the control group, showing a statistical difference (P<0.05).
Conclusion: Moxibustion plus Duhuo Jisheng decoction has a good clinical effect for middle-aged and elderly KOA patients,
and the effect may relate to the decreased hs-CRP, IL-1β and TNF-α levels.
Keywords: Moxibustion Therapy; Osteoarthritis, Knee; C-reactive Protein; Interleukin-1beta; Tumor Necrosis Factor-alpha
介素-1β (IL-1β)和肿瘤坏死因子-α (TNF-α)水平的影响, 并观察临床疗效。方法：共纳入90例 KOA 患者, 按随机数
字表法分为观察组和对照组, 每组45例。对照组予以口服独活寄生汤治疗, 观察组在对照组治疗的基础上加用艾
灸治疗, 观察两组患者治疗前后炎性因子 hs-CRP、IL-1β 和 TNF-α 水平的变化并比较其临床疗效。结果：治疗前
P、IL-1β 和 TNF-α 水平均无统计学差异(均 P＞0.05)。治疗8星期后, 两组的 hs-CRP、IL-1β 和 TNF-α
水平均明显下降(P＜0.01或 P＜0.05), 且观察组下降幅度较对照组更明显(均 P＜0.05)。观察组总有效率97.8%, 明
显优于对照组的86.7% (P＜0.05)。结论：艾灸联合独活寄生汤治疗中老年 KOA 具有良好的临床疗效, 其机理可能
与降低患者的炎性因子 hs-CRP、IL-1β 和 TNF-α 有关。
【关键词】灸法; 关节炎, 膝; C-反应蛋白; 白细胞介素-1β; 肿瘤坏死因子-α
Knee osteoarthritis (KOA) is a common degenerative
joint disease among the middle-aged and elderly
people. It is generally caused by strain of peripheral
ligament, and subsequent lesion of the joint cartilage
may lead to swelling, pain, osteoproliferation or even
. The cause of KOA is
complicated and requires further investigation.
Author: Nong Xian-gang, attending physician.
Currently, in traditional Chinese medicine (TCM),
there is much progress in treating KOA, such as
medicinal herbs, which can activate blood and resolve
stasis and non-pharmaceutical therapy. They all showed
a good clinical effect, in which, moxibustion especially
shows a more substantial effect. We’ve treated KOA
patients with moxibustion plus Duhuo Jisheng
decoction and the levels of high sensitive C-reactive
protein (hs-CRP), interleukin-1β (IL-1β) and tumor
necrosis factor-α (TNF-α) were examined. The results
are summarized as follows.