Effect of Four Coat Color Mutations (Cr, S, SH, and h) on Brain Monoamine Oxidase in Mink

Effect of Four Coat Color Mutations (Cr, S, SH, and h) on Brain Monoamine Oxidase in Mink Activity of A and B types of monoamine oxidase (MAO) has been investigated in the brain stem and brain hemispheres of mink males of five genotypes for coat color mutations: standard dark-brown (+/+); heterozygous for the semidominant mutation Black crystal(Cr/+); homozygous for the semidominant mutation Black cross, or “95% White” (S/S); heterozygous for the semidominant mutationShadow(S H/+); and homozygous for the semirecessive mutation hedlund white(h/h). The main changes in the activity of the A and B MAO types occur in the brain hemispheres. A reduced activity of MAO A has been recorded in the hemispheres of Black crystalminks (Cr/+) and an elevated activity, in the hemispheres of Shadow(S H/+) and 95% White(S/S). The activity of MAO B is reduced in the hemispheres of Black crystaland elevated in the hemispheres of hedlund white(h/h). An increased MAO A activity has also been recorded in the brain stem of Shadowminks (S H/+). It is suggested that genes controlling coat color have a pleiotropic effect on sexual behavior in males and the endocrine function of testicles mediated by a putative change in the metabolism of brain neurotransmitters, substrates of MAOs A and B. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Effect of Four Coat Color Mutations (Cr, S, SH, and h) on Brain Monoamine Oxidase in Mink

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Publisher
Kluwer Academic Publishers-Plenum Publishers
Copyright
Copyright © 2001 by MAIK “Nauka/Interperiodica”
Subject
Biomedicine; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1023/A:1016666631573
Publisher site
See Article on Publisher Site

Abstract

Activity of A and B types of monoamine oxidase (MAO) has been investigated in the brain stem and brain hemispheres of mink males of five genotypes for coat color mutations: standard dark-brown (+/+); heterozygous for the semidominant mutation Black crystal(Cr/+); homozygous for the semidominant mutation Black cross, or “95% White” (S/S); heterozygous for the semidominant mutationShadow(S H/+); and homozygous for the semirecessive mutation hedlund white(h/h). The main changes in the activity of the A and B MAO types occur in the brain hemispheres. A reduced activity of MAO A has been recorded in the hemispheres of Black crystalminks (Cr/+) and an elevated activity, in the hemispheres of Shadow(S H/+) and 95% White(S/S). The activity of MAO B is reduced in the hemispheres of Black crystaland elevated in the hemispheres of hedlund white(h/h). An increased MAO A activity has also been recorded in the brain stem of Shadowminks (S H/+). It is suggested that genes controlling coat color have a pleiotropic effect on sexual behavior in males and the endocrine function of testicles mediated by a putative change in the metabolism of brain neurotransmitters, substrates of MAOs A and B.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Oct 16, 2004

References

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