Arch Gynecol Obstet (2017) 296:421–427 DOI 10.1007/s00404-017-4404-y REVIEW Effect of epilepsy in pregnancy on fetal growth restriction: a systematic review and meta-analysis 1,2 3 1,2 1,4 1,4 • • • • Daijuan Chen Lisha Hou Xia Duan Hongling Peng Bing Peng Received: 4 March 2017 / Accepted: 16 May 2017 / Published online: 23 June 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract epileptic pregnant women than in non-epileptic women Purpose Epilepsy is one of the most common neurological [95% conﬁdence interval (95% CI) 1.09–1.50, p\ 0.05]. diseases during pregnancy. However, the inﬂuence of Given the course of previous studies, hierarchical analysis epilepsy on fetal growth is not understood. Thus, this study of pregnant women who use antiepileptic drugs (AEDs) conducted a meta-analysis to determine the inﬂuence of was conducted. Results show that FGR rate is signiﬁcantly epilepsy during pregnancy on fetal growth restriction increased even if AEDs were taken [odds ratio 1.26, 95% (FGR). CI 1.13–1.41, p\ 0.05]. Methods BIOSIS, Medline, Embase, and PubMed data- Conclusions Although modest bias cannot be avoided, our bases were searched between January 2000 and January meta-analysis indicated that epilepsy participates in fetal 2016. Without imposing language or regional restrictions, development as an unfavorable factor,
Archives of Gynecology and Obstetrics – Springer Journals
Published: Jun 23, 2017
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