The turmeric extract nanoparticles were synthesized by complexation involving modified carboxylmethyl cellulose (MCMC) and calcium ions. The effect of viscosity of carboxylmethyl cellulose (CMC) solution on the particle size of turmeric extract nanoparticle was investigated. Firstly, MCMC viscosity decreases with the increase of H2O2 content (as observed from weight ratio between MCMC and CMC) due to chain scission. The chemical structure of CMC was slightly altered after modification as confirmed by ATR-FTIR and XRD. The parameters affecting the nanoparticle size were investigated using Zetasizer. The resulting nanoparticle size decreased with the increase in the added CaCl2 amount up to the optimal level as observed from dynamic viscosity measurements due to the agglomeration of MCMC chains. Moreover, the nanoparticle size was reduced with increased content of turmeric extract dissolved in ethanol since ethanol is a poor solvent for CMC. However, the nanoparticle size increased with the increase of MCMC concentration due to the growth of MCMC dynamic viscosity. The Zeta potential of nanoparticles reaches the maximum at the lowest CaCl2 concentration. After drying, the aggregation of nanoparticles appeared as observed by SEM and TEM. Finally, the obtained nanoparticles are promising for colon cancer therapy as shown by 98–99% inhibition of colon cancer in the performed tests.
Russian Journal of Applied Chemistry – Springer Journals
Published: Jan 23, 2015
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