A natural complex of avermectins, aversectin C, and a component of this complex, avermectin A1, were shown to change the conductivity of Ca2+-dependent Cl− channels of plasmalemma of Chara corallina cells by acting from the outer side of the cellular membrane. Low concentrations of aversectin C and avermectin A1 increased the Cl− current: K 1/2= 35 ng/ml for the whole complex and K 1/2= 21 pg/ml for A1. Relatively high concentrations of the compounds suppressed the Cl− current: K 1/2= 2.2 μg/ml for aversectin C and K 1/2= 4.2 ng/ml for A 1. The Hill coefficient for the interaction of avermectin A 1 with the corresponding targets was identical for stimulation and suppression of the Cl− current: 2.8 and 2.5, respectively. Bicuculline, a nonspecific inhibitor of the GABA a receptors, did not influence stimulation of Cl− currents caused by low concentrations of avermectins, but at the same time blocked suppression of the Cl− currents by high concentrations of avermectins. Avermectins A2, B1, B2, abamectin and 22,23-dihydroavermectin B1 (ivermectin) did not affect the Cl− currents of Chara corallina cells.
The Journal of Membrane Biology – Springer Journals
Published: Jul 1, 2001
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