Effect of Avermectins on Ca2+-dependent Cl− Currents in Plasmalemma of Chara corallina Cells

Effect of Avermectins on Ca2+-dependent Cl− Currents in Plasmalemma of Chara corallina Cells A natural complex of avermectins, aversectin C, and a component of this complex, avermectin A1, were shown to change the conductivity of Ca2+-dependent Cl− channels of plasmalemma of Chara corallina cells by acting from the outer side of the cellular membrane. Low concentrations of aversectin C and avermectin A1 increased the Cl− current: K 1/2= 35 ng/ml for the whole complex and K 1/2= 21 pg/ml for A1. Relatively high concentrations of the compounds suppressed the Cl− current: K 1/2= 2.2 μg/ml for aversectin C and K 1/2= 4.2 ng/ml for A 1. The Hill coefficient for the interaction of avermectin A 1 with the corresponding targets was identical for stimulation and suppression of the Cl− current: 2.8 and 2.5, respectively. Bicuculline, a nonspecific inhibitor of the GABA a receptors, did not influence stimulation of Cl− currents caused by low concentrations of avermectins, but at the same time blocked suppression of the Cl− currents by high concentrations of avermectins. Avermectins A2, B1, B2, abamectin and 22,23-dihydroavermectin B1 (ivermectin) did not affect the Cl− currents of Chara corallina cells. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Effect of Avermectins on Ca2+-dependent Cl− Currents in Plasmalemma of Chara corallina Cells

Loading next page...
Copyright © Inc. by 2001 Springer-Verlag New York
Life Sciences; Biochemistry, general; Human Physiology
Publisher site
See Article on Publisher Site

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial