Cardiovasc Drugs Ther (2017) 31:295–301 DOI 10.1007/s10557-017-6728-z ORIGINAL ARTICLE Effect of Apixaban on All-Cause Death in Patients with Atrial Fibrillation: a Meta-Analysis Based on Imputed Placebo Effect 1 1 1 Patrícia O. Guimarães & Renato D. Lopes & Daniel M. Wojdyla & 2 3 4 5 Azmil H. Abdul-Rahim & Stuart J. Connolly & Greg C. Flaker & Junyuan Wang & 6 1 7 2 Michael Hanna & Christopher B. Granger & Lars Wallentin & Kennedy R. Lees & 1 2 John H. Alexander & John J.V. McMurray Published online: 18 May 2017 Springer Science+Business Media New York 2017 Abstract patients with AF. We used results from meta-analyses of Purpose Vitamin K antagonists (VKAs) are the standard of randomized trials as our reference for the comparison between care for stroke prevention in patients with atrial fibrillation warfarin and placebo/no treatment, and aspirin and placebo/no (AF); therefore, there is not equipoise when comparing newer treatment. oral anticoagulants with placebo in this setting. Results In these meta-analyses, a lower rate of death was seen Methods To explore the effect of apixaban on mortality in both with warfarin (odds ratio [OR] 0.74, 95% confidence in- patients with AF, we performed a meta-analysis
Cardiovascular Drugs and Therapy – Springer Journals
Published: May 18, 2017
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