Editorial: Special Issue on Heart Valve Mechanobiology

Editorial: Special Issue on Heart Valve Mechanobiology Cardiovascular Engineering and Technology, Vol. 9, No. 2, June 2018 ( 2018) pp. 121–125 https://doi.org/10.1007/s13239-018-0360-3 New Insights into Mechanical Regulation of Valve Disease and Regeneration Heart valve diseases—both ‘‘degenerative’’ etiolo- For pediatric patients with congenital disease gies associated with aging and rheumatic disease in affecting their valves, tissue engineering holds great developing countries—affect ~ 2–3% of the world’s potential to provide replacement valves that can inte- population. Medical treatments for the most com- grate, grow, and adapt with the child. Although recent mon valvular diseases are largely nonexistent, and as reports show early promise for tissue engineered valve 3,27 such valvular surgeries now make up more than 20% replacements in sheep and evidence of somatic 10 26 of all cardiac surgeries. While there have been sig- growth of vascular grafts in lambs, clinical transla- nificant advances in minimally-invasive surgical inter- tion has yet to be achieved. To this end, better ventions for valvular diseases in the past decade, understanding of how multiple regulatory factors there remain unmet needs for alternative therapies that individually and integratively influence cell function, are broadly applicable, enable early intervention be- tissue formation and organization, and mechanical fore significant deterioration in quality of life, and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cardiovascular Engineering and Technology Springer Journals

Editorial: Special Issue on Heart Valve Mechanobiology

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Publisher
Springer US
Copyright
Copyright © 2018 by Biomedical Engineering Society
Subject
Engineering; Biomedical Engineering; Cardiology; Biomedicine, general
ISSN
1869-408X
eISSN
1869-4098
D.O.I.
10.1007/s13239-018-0360-3
Publisher site
See Article on Publisher Site

Abstract

Cardiovascular Engineering and Technology, Vol. 9, No. 2, June 2018 ( 2018) pp. 121–125 https://doi.org/10.1007/s13239-018-0360-3 New Insights into Mechanical Regulation of Valve Disease and Regeneration Heart valve diseases—both ‘‘degenerative’’ etiolo- For pediatric patients with congenital disease gies associated with aging and rheumatic disease in affecting their valves, tissue engineering holds great developing countries—affect ~ 2–3% of the world’s potential to provide replacement valves that can inte- population. Medical treatments for the most com- grate, grow, and adapt with the child. Although recent mon valvular diseases are largely nonexistent, and as reports show early promise for tissue engineered valve 3,27 such valvular surgeries now make up more than 20% replacements in sheep and evidence of somatic 10 26 of all cardiac surgeries. While there have been sig- growth of vascular grafts in lambs, clinical transla- nificant advances in minimally-invasive surgical inter- tion has yet to be achieved. To this end, better ventions for valvular diseases in the past decade, understanding of how multiple regulatory factors there remain unmet needs for alternative therapies that individually and integratively influence cell function, are broadly applicable, enable early intervention be- tissue formation and organization, and mechanical fore significant deterioration in quality of life, and

Journal

Cardiovascular Engineering and TechnologySpringer Journals

Published: May 14, 2018

References

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