Cardiovascular Engineering and Technology, Vol. 9, No. 2, June 2018 ( 2018) pp. 121–125 https://doi.org/10.1007/s13239-018-0360-3 New Insights into Mechanical Regulation of Valve Disease and Regeneration Heart valve diseases—both ‘‘degenerative’’ etiolo- For pediatric patients with congenital disease gies associated with aging and rheumatic disease in aﬀecting their valves, tissue engineering holds great developing countries—aﬀect ~ 2–3% of the world’s potential to provide replacement valves that can inte- population. Medical treatments for the most com- grate, grow, and adapt with the child. Although recent mon valvular diseases are largely nonexistent, and as reports show early promise for tissue engineered valve 3,27 such valvular surgeries now make up more than 20% replacements in sheep and evidence of somatic 10 26 of all cardiac surgeries. While there have been sig- growth of vascular grafts in lambs, clinical transla- niﬁcant advances in minimally-invasive surgical inter- tion has yet to be achieved. To this end, better ventions for valvular diseases in the past decade, understanding of how multiple regulatory factors there remain unmet needs for alternative therapies that individually and integratively inﬂuence cell function, are broadly applicable, enable early intervention be- tissue formation and organization, and mechanical fore signiﬁcant deterioration in quality of life, and
Cardiovascular Engineering and Technology – Springer Journals
Published: May 14, 2018
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