Mamm Genome (2008) 19:1 DOI 10.1007/s00335-007-9091-8 Steve D. M. Brown Æ Joe Nadeau Æ Maja Bucan Received: 18 December 2007 / Accepted: 18 December 2007 / Published online: 15 January 2008 Springer Science+Business Media, LLC 2007 Mammalian Genome continues to publish research and problems in bioinformatics and data analysis to challenges commentary at the forefront of mammalian functional in infrastructure and resources provision. We hope you will genomics, and 2008 will be no exception. First, excitingly we be stimulated and intrigued. We welcome suggestions for are in the midst of preparing 2008’s special issue, which will this series and are happy to receive proposals, or drafts, for focus on noncoding RNAs. Recent research has revealed that consideration. much more of the genome is transcribed than we had origi- We also would like to take this opportunity each year to nally expected, with whole new classes of transcripts emphasize areas of mammalian genetics research for which emerging, from microRNAs to antisense RNAs. We are only we are particularly keen to encourage submissions. Phe- just beginning to understand the functional role of these notyping is one of the key challenges for mammalian classes of transcripts, but if we are to develop a systems genetics in the coming decade. With ever more sophisti- biology of mammals, we have to decipher their contribution cated and high-throughput approaches to mutagenesis, we to and function within transcriptional networks and their are on the cusp of being able to generate a variety of mutant consequences for development, physiology, and biochem- alleles for every gene in the mouse genome—ENU mutants, istry. The 2008 special issue will include both reviews and knockouts, gene traps, and transposon mutants. We are sure original articles, and we look forward to publishing a volume that new approaches in mutagenesis will continue to that provides an informative marker of progress in this area. emerge. However, if we are to truly develop a systems We are also instituting a new series of commentaries on biology of the mammal, we will need to undertake a com- ‘‘Challenges and Opportunities in Mammalian Functional prehensive phenotypic assessment of each and every mutant Genomics.’’ The aim of these articles, which will appear in allele—an enormous and daunting task. In the spirit of this each issue, is to garner a contemporary perspective on the venture, we welcome articles that cover the development exciting developments in mammalian genetics. The articles and application of phenotypic screens to mutagenesis pro- will be catholic in scope, ranging from horizon scanning on grams, for example, articles that reveal new classes of emerging areas in mammalian genetics to ongoing phenotypes or demonstrate large-scale and broad-based determination of phenotypes. In addition, we invite articles that make a signiﬁcant contribution to the development of S. D. M. Brown (&) phenotyping platforms or approaches for mammals. Last MRC Mammalian Genetics Unit, Medical Research Council, Harwell, Oxfordshire OX11 0RD, UK but not least, the informatics problems of phenotyping are e-mail: email@example.com formidable; we encourage the submission of articles that address and tackle developments in the informatics of J. Nadeau phenotyping, including databases and ontologies. Genetics Department, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106-4955, USA In deciphering the relationship between gene and phe- notype, Mammalian Genome aims to continue to make a M. Bucan pivotal contribution by publishing seminal contributions in Department of Genetics, University of Pennsylvania School of mammalian functional genomics, and we look forward to Medicine, 528 Clinical Research Building, 415 Curie Boulevard, another year of exciting progress and reading. Philadelphia, PA 19104, USA
Mammalian Genome – Springer Journals
Published: Jan 15, 2008
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