To study the role the phenyl group plays in producing local anesthetic block, a sequence of n-alkanols and phenyl-substituted alkanols (Φ-alkanols) were characterized in their ability to block Na channels. The sequence of n-alkanols studied possess 3–5 carbons (propanol-pentanol). The action of phenol and 3-Φ-alkanols (benzyl alcohol, phenethyl alcohol, 3-phenyl-1-propanol) were also studied. Na currents (I Na ) were recorded from single frog skeletal muscle fibers using the Vaseline-gap voltage clamp technique. I Na s were recorded prior to, during, and following the removal of the solutes in Ringer's solution.
The Journal of Membrane Biology – Springer Journals
Published: Mar 15, 2001
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