PharmacoEconomics & Outcomes News 792, p10 - 2 Dec 2017 Economic studies of vaccines use static model of herd immunity Most economic studies of vaccines use static models for estimating herd immunity, according to findings of a systematic review of the methodology used which was published in Vaccine. Investigators used data from a previous systematic review of models used in cost-effectiveness evaluations of vaccines between 1976 and 2007, and searched PubMed/MEDLINE and Embase databases for similar evaluations published between 2007 and 2015. Of 625 economic evaluations which met the selection criteria, 172 included herd immunity. Herd immunity was included in 53% of studies published in 2015 compared with only 4% of studies published in 2001, and was considered in 63% of evaluations of human papillomavirus vaccines, pneumococcal vaccines and rotavirus vaccines. Only 59 of the studies which considered herd immunity used a dynamic model; 95 studies used a static model and eight used a hybrid model The method of modelling was not clearly stated in ten studies. Most of the studies which used a static model used "relatively crude methods and assumptions," said the investigators. "Values from a static model can only be considered reliable if high quality surveillance data are incorporated into the analysis. Without this, the results are questionable and they should only be included in sensitivity analysis," they commented. Nymark LS, et al. Inclusion of the value of herd immunity in economic evaluations of vaccines. A systematic review of methods used. Vaccine : 13 Nov 2017. Available from: URL: http://doi.org/10.1016/j.vaccine.2017.10.024 803284958 1173-5503/17/0792-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved PharmacoEconomics & Outcomes News 2 Dec 2017 No. 792
PharmacoEconomics & Outcomes News – Springer Journals
Published: Dec 2, 2017
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