Keywords 1,8-Naphthyridines Green synthesis Antimicrobial activity Molecular docking Introduction 1,8-Naphthyridines are a signiﬁcant class of heterocyclic compounds of which numerous derivatives have been originated with varied and attractive biological and chemical importance [1–3]. They also show antiplatelet activity , antibacterial , antihypertensive , antitumor , anti-inﬂammatory , anti-allergic , antimalarial , anti-HIV , and gastric anti-secretary activities , while nalidixic acid possesses strapping antibacterial activity and is used effectively for the treatment of urinary tract infections . A number of other remarkable applications have also been reported in the literature, for example potent inhibition of protein kinase C isozymes , discriminatory inhibition of p38 mitogen- activated proteinkinase , Acyl-CoA: cholesterolacyltransferase (ACAT) inhibi- tory activity , and mycobacterium tuberculosis activity . Some of the biologically active 1,8-naphthyridine derivatives are shown in Fig. 1. 123 Eco-friendly synthesis of 1,8-naphthyridine… 1883 Fig. 1 Chemical structure of the some potent 1,8-naphthyridines In recent years, with increasing public interest over environmental degradation, one of the most important tasks for chemists is to come up with innovative approaches that are less hazardous to anthropoid health and the environment. Organic reactions in the solvent-free solid-state grinding method have been attracting synthetic organic researchers because
Research on Chemical Intermediates – Springer Journals
Published: Sep 21, 2016
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