Eco-friendly synthesis of 1,8-naphthyridine 5-aryl-1,3,4-oxadiazole derivatives under solvent-free solid-state conditions and their antimicrobial activity

Eco-friendly synthesis of 1,8-naphthyridine 5-aryl-1,3,4-oxadiazole derivatives under... Keywords 1,8-Naphthyridines  Green synthesis  Antimicrobial activity Molecular docking Introduction 1,8-Naphthyridines are a significant class of heterocyclic compounds of which numerous derivatives have been originated with varied and attractive biological and chemical importance [1–3]. They also show antiplatelet activity [4], antibacterial [5], antihypertensive [6], antitumor [7], anti-inflammatory [8], anti-allergic [9], antimalarial [10], anti-HIV [11], and gastric anti-secretary activities [12], while nalidixic acid possesses strapping antibacterial activity and is used effectively for the treatment of urinary tract infections [13]. A number of other remarkable applications have also been reported in the literature, for example potent inhibition of protein kinase C isozymes [14], discriminatory inhibition of p38 mitogen- activated proteinkinase [15], Acyl-CoA: cholesterolacyltransferase (ACAT) inhibi- tory activity [16], and mycobacterium tuberculosis activity [17]. Some of the biologically active 1,8-naphthyridine derivatives are shown in Fig. 1. 123 Eco-friendly synthesis of 1,8-naphthyridine… 1883 Fig. 1 Chemical structure of the some potent 1,8-naphthyridines In recent years, with increasing public interest over environmental degradation, one of the most important tasks for chemists is to come up with innovative approaches that are less hazardous to anthropoid health and the environment. Organic reactions in the solvent-free solid-state grinding method have been attracting synthetic organic researchers because http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Eco-friendly synthesis of 1,8-naphthyridine 5-aryl-1,3,4-oxadiazole derivatives under solvent-free solid-state conditions and their antimicrobial activity

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Publisher
Springer Netherlands
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2736-z
Publisher site
See Article on Publisher Site

Abstract

Keywords 1,8-Naphthyridines  Green synthesis  Antimicrobial activity Molecular docking Introduction 1,8-Naphthyridines are a significant class of heterocyclic compounds of which numerous derivatives have been originated with varied and attractive biological and chemical importance [1–3]. They also show antiplatelet activity [4], antibacterial [5], antihypertensive [6], antitumor [7], anti-inflammatory [8], anti-allergic [9], antimalarial [10], anti-HIV [11], and gastric anti-secretary activities [12], while nalidixic acid possesses strapping antibacterial activity and is used effectively for the treatment of urinary tract infections [13]. A number of other remarkable applications have also been reported in the literature, for example potent inhibition of protein kinase C isozymes [14], discriminatory inhibition of p38 mitogen- activated proteinkinase [15], Acyl-CoA: cholesterolacyltransferase (ACAT) inhibi- tory activity [16], and mycobacterium tuberculosis activity [17]. Some of the biologically active 1,8-naphthyridine derivatives are shown in Fig. 1. 123 Eco-friendly synthesis of 1,8-naphthyridine… 1883 Fig. 1 Chemical structure of the some potent 1,8-naphthyridines In recent years, with increasing public interest over environmental degradation, one of the most important tasks for chemists is to come up with innovative approaches that are less hazardous to anthropoid health and the environment. Organic reactions in the solvent-free solid-state grinding method have been attracting synthetic organic researchers because

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Sep 21, 2016

References

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