J Cancer Res Clin Oncol (2017) 143:1815–1821 DOI 10.1007/s00432-017-2423-5 ORIGINAL ARTICLE – CLINICAL ONCOLOGY Early whole brain radiotherapy in primary CNS lymphoma: negative impact on quality of life in the randomized G‑PCNSL‑SG1 trial 1,2 1 3 4 5 6 Ulrich Herrlinger · Niklas Schäfer · Rolf Fimmers · Frank Griesinger · Michael Rauch · Heinz Kirchen · 7 1,8 9 10 11 11 Patrick Roth · Martin Glas · Michael Bamberg · Peter Martus · Eckhard Thiel · Agnieszka Korfel · 2,7 Michael Weller Received: 9 January 2017 / Accepted: 11 April 2017 / Published online: 22 April 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract Methods QoL measurements were performed using the Purpose In the randomized G-PCNSL-SG-1 trial, the EORTC-QLQ-C30 and BN20 questionnaires and combined addition of whole brain radiotherapy (45 Gy) to high- with repeated Mini Mental State Examinations (MMSE). dose methotrexate (HD-MTX)-based chemotherapy (early Exploratory data analysis included the 318 patients in the WBRT arm) did not prolong overall survival (OS) as com- per-protocol population. pared to HD-MTX-based chemotherapy alone (no early Results In year 2 after randomization, cognitive func- WBRT arm) in primary CNS lymphoma (PCNSL) patients. tioning and global health status were reduced in the
Journal of Cancer Research and Clinical Oncology – Springer Journals
Published: Apr 22, 2017
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