Background The purpose of this study was to analyze the therapy in elderly patients with early-stage NSCLC is increas- patterns of care of local therapies and their impact on overall ing in the USA. Given its generally favorable toxicity profile, survival (OS) among elderly patients with early-stage non- SBRT should be considered in the substantial proportion of small cell lung cancer (NSCLC) in the USA. elderly patients still not receiving any definitive local therapy. Methods The National Cancer Database was queried for pa- Among medically operable elderly patients, OS was similar tients at least age 80 years with NSCLC diagnosed in 2004– between resection and SBRT. 2013 with clinical stage T1–3N0M0. Local therapy was ana- lyzed over time and by age. Multivariable (MVA) models . . . . Keywords Lung cancer NCDB SBRT SABR were performed to investigate the impact of prognostic factors . . Lobectomy Radiation NSCLC on OS. Results Among 40,561 patients meeting inclusion criteria, 17,418 (43%), 13,008 (32%), and 10,135 (25%) of patients underwent surgical resection, radiotherapy, and observation, Introduction respectively, as their initial mode of local therapy. Overtime, while the utilization of surgical managements generally In the USA, non-small cell lung cancer (NSCLC) is the
Journal of Radiation Oncology – Springer Journals
Published: May 25, 2017
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