Pathology & Oncology Research https://doi.org/10.1007/s12253-018-0424-6 LETTER TO THE EDITOR Early Skin Rash and Cetuximab-Based Therapy of Advanced Biliary Tract Cancer 1,2,3,4,5,6 Viroj Wiwanitkit Received: 8 May 2017 /Accepted: 28 May 2018 Arányi Lajos Foundation 2018 Dear Editor, the recent report on BEarlySkinRashand Compliance with ethical standards Cetuximab-Based Therapy of Advanced Biliary Tract Conflict of interest None. Cancer^ is very interesting . Rubovszky et al. sug- gested that Bearly skin rash can be used as a biomarker to select patients who would benefit from the treatment with cetuximab plus chemotherapy .^ In fact, skin References rash is a paraneoplastic sign in advance biliary tract cancer . The sign might be a possible biomarker 1. Rubovszky G, Budai B, Ganofszky E, Horváth Z, Juhos É, Madaras but there are some concerns. First, the skin rash can B, Nagy T,Szabó E,Pintér T,TóthE,Nagy P,LángI,Hitre E(2017 be due to other causes (such as irritant contact) and this Apr 29) Predictive Value of Early Skin Rash in Cetuximab-Based cannot be ruled out in the present report by Rubovszky Therapy of Advanced Biliary Tract Cancer. Pathol Oncol Res. et al. Dermatological investigation is required for diag- https://doi.org/10.1007/s12253-017-0238-y [Epub ahead of print] 2. Opneja A, Mahajan S, Kapoor S, Marur S, Yang SH, Manno R nosis of the skin rash. Second, the cause of advanced (2015) Unusual P araneopl astic P rese nt ation of biliary tract cancer can be due to the infectious etiology. Cholangiocarcinoma. Case Rep Med 2015:806835 In my setting in Southeast Asia, liver fluke is the main 3. MacLean JD, Graeme-Cook FM (2002 Apr 18) Case records of the infection that leads to advanced biliary tract cancer. Of Massachusetts General Hospital. Weekly clinicopathological exer- interest, the liver fluke infestation can also induce the cises. Case 12-2002. A 50-year-old man with eosinophilia and fluc- tuating hepatic lesions. N Engl J Med 346(16):1232–1239 skin rash . * Viroj Wiwanitkit firstname.lastname@example.org Hainan Medical University, Haikou, China WiwanitkitHouse, Bangkhae, Bangkok 10160, Thailand dr DY Patil University, Navi Mumbai, India Faculty of Medicine, University of Nis, Niš,Serbia Joseph Ayobabalola University, Ilara-Mokin, Nigeria Surindra Rajabhat University, Surin, Thailand
Pathology & Oncology Research – Springer Journals
Published: Jun 1, 2018
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