Early Postnatal Development of the Lamination in the Lateral Geniculate Nucleus A-Layers in Cats

Early Postnatal Development of the Lamination in the Lateral Geniculate Nucleus A-Layers in Cats The early postnatal development of the A-layers of the dorsal lateral geniculate nucleus (LGNd) was investigated in kittens aged 0–34 days by immunohistochemistry for the selective marker for neuronal differentiation (NeuN protein) and parvalbumin. We report two new facts about the LGNd development. First, there is a transient stratification of NeuN labelling in layer A, and to a lesser extent in layer A1, in kittens aged 0 and 4 days. Second, a transient population of large cells that are located between the LGNd A-layers (interlaminar cells) showed high expression levels of both NeuN and parvalbumin. These neurons possessed both the morphological and immunohistochemical features, similar to cells in the neighbouring perigeniculate nucleus. Both NeuN-stratification and double-stained interlaminar cells gradually disappeared during the second postnatal week, and almost completely vanished by the opening of the critical period. We discuss a possible linkage between these observed transitory networks and the ON-/OFF- and X-/Y-cells development and propose that the data obtained reflect the functioning of the early environmentally independent geniculate networks. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cellular and Molecular Neurobiology Springer Journals

Early Postnatal Development of the Lamination in the Lateral Geniculate Nucleus A-Layers in Cats

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Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Biomedicine; Neurosciences; Cell Biology; Neurobiology
ISSN
0272-4340
eISSN
1573-6830
D.O.I.
10.1007/s10571-018-0585-6
Publisher site
See Article on Publisher Site

Abstract

The early postnatal development of the A-layers of the dorsal lateral geniculate nucleus (LGNd) was investigated in kittens aged 0–34 days by immunohistochemistry for the selective marker for neuronal differentiation (NeuN protein) and parvalbumin. We report two new facts about the LGNd development. First, there is a transient stratification of NeuN labelling in layer A, and to a lesser extent in layer A1, in kittens aged 0 and 4 days. Second, a transient population of large cells that are located between the LGNd A-layers (interlaminar cells) showed high expression levels of both NeuN and parvalbumin. These neurons possessed both the morphological and immunohistochemical features, similar to cells in the neighbouring perigeniculate nucleus. Both NeuN-stratification and double-stained interlaminar cells gradually disappeared during the second postnatal week, and almost completely vanished by the opening of the critical period. We discuss a possible linkage between these observed transitory networks and the ON-/OFF- and X-/Y-cells development and propose that the data obtained reflect the functioning of the early environmentally independent geniculate networks.

Journal

Cellular and Molecular NeurobiologySpringer Journals

Published: Apr 17, 2018

References

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