The goal of the present study was to investigate the biochemical and histological changes in dog’s kidney, liver, heart, and skeletal muscles within 72 h after death. Ten male mongrel dogs aged from 1 to 2 years old were subjected to this study. Dogs were euthanized by the rapid intravenous injection of a lethal dose of sodium thiopental, and then the liver, kidney, heart, and skeletal muscle samples were collected from the whole carcasses at different time intervals 4, 12, 24, 48, and 72 h postmortem. Samples were divided into two parts; one part was used for measuring tissue levels of lactate dehydro- genase (LDH), lactate, creatine phosphokinase (CPK), and aspartate aminotransferase (AST). The other part was subjected to histopathological examinations. On the biochemical level, LDH in the liver, kidney, and cardiac and skeletal muscles showed a significant increase at 4 h followed by significant decrease at 48 and 72 h in all the studied tissues. Lactate level showed variable degrees of increase and decrease in kidney and liver tissues while muscles showed increased lactate concentration during the first 48 h then decreased at 72 h. CPK in cardiac and skeletal muscles showed similar changes; it increased from4 to
Comparative Clinical Pathology – Springer Journals
Published: Jun 5, 2018
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