Early Effects of Sleeve Gastrectomy on Obesity-Related Cytokines and Bile Acid Metabolism in Morbidly Obese Japanese Patients

Early Effects of Sleeve Gastrectomy on Obesity-Related Cytokines and Bile Acid Metabolism in... Background Laparoscopic sleeve gastrectomy (LSG) has increased FGF-19 secretion soon after surgery, and slowly wide-ranging positive effects on adipocytokine metabolism, ameliorated inflammation related to obesity through signifi- bile acid profile, and chronic low-grade inflammation related cant weight loss. to obesity. However, the early temporal changes in these . . markers following LSG have not been well investigated. Keywords Sleeve gastrectomy Adipocytokine This study aimed to evaluate the early effects of LSG on Inflammation Bile acids adipocytokines, bile acid profile, and inflammatory markers. Methods This was a nonrandomized prospective study exam- ining morbidly obese Japanese patients undergoing LSG. Introduction Serial measurements of leptin, adiponectin, bile acids, fibro- blast growth factor (FGF)-19, and inflammatory markers were The pathophysiology of obesity is multi-factorial. performed preoperatively and 1 and 6 months after LSG. Adipocytokines released by macrophages and adipocytes play Results The study included ten patients (five females) with a an important role in the pathogenesis of obesity and metabolic mean age of 48.8 years and BMI 40.9 kg/m . At baseline, 90% complications. Changes in weight and fat mass affect of the patients had T2DM, 70% had dyslipidemia, and 90% adiponectin and leptin metabolism. While an increase in had hypertension. Patients lost http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Obesity Surgery Springer Journals

Early Effects of Sleeve Gastrectomy on Obesity-Related Cytokines and Bile Acid Metabolism in Morbidly Obese Japanese Patients

Loading next page...
 
/lp/springer_journal/early-effects-of-sleeve-gastrectomy-on-obesity-related-cytokines-and-i52tJcMyXs
Publisher
Springer US
Copyright
Copyright © 2017 by Springer Science+Business Media New York
Subject
Medicine & Public Health; Surgery
ISSN
0960-8923
eISSN
1708-0428
D.O.I.
10.1007/s11695-017-2756-9
Publisher site
See Article on Publisher Site

Abstract

Background Laparoscopic sleeve gastrectomy (LSG) has increased FGF-19 secretion soon after surgery, and slowly wide-ranging positive effects on adipocytokine metabolism, ameliorated inflammation related to obesity through signifi- bile acid profile, and chronic low-grade inflammation related cant weight loss. to obesity. However, the early temporal changes in these . . markers following LSG have not been well investigated. Keywords Sleeve gastrectomy Adipocytokine This study aimed to evaluate the early effects of LSG on Inflammation Bile acids adipocytokines, bile acid profile, and inflammatory markers. Methods This was a nonrandomized prospective study exam- ining morbidly obese Japanese patients undergoing LSG. Introduction Serial measurements of leptin, adiponectin, bile acids, fibro- blast growth factor (FGF)-19, and inflammatory markers were The pathophysiology of obesity is multi-factorial. performed preoperatively and 1 and 6 months after LSG. Adipocytokines released by macrophages and adipocytes play Results The study included ten patients (five females) with a an important role in the pathogenesis of obesity and metabolic mean age of 48.8 years and BMI 40.9 kg/m . At baseline, 90% complications. Changes in weight and fat mass affect of the patients had T2DM, 70% had dyslipidemia, and 90% adiponectin and leptin metabolism. While an increase in had hypertension. Patients lost

Journal

Obesity SurgerySpringer Journals

Published: May 31, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off