Background Laparoscopic sleeve gastrectomy (LSG) has increased FGF-19 secretion soon after surgery, and slowly wide-ranging positive effects on adipocytokine metabolism, ameliorated inflammation related to obesity through signifi- bile acid profile, and chronic low-grade inflammation related cant weight loss. to obesity. However, the early temporal changes in these . . markers following LSG have not been well investigated. Keywords Sleeve gastrectomy Adipocytokine This study aimed to evaluate the early effects of LSG on Inflammation Bile acids adipocytokines, bile acid profile, and inflammatory markers. Methods This was a nonrandomized prospective study exam- ining morbidly obese Japanese patients undergoing LSG. Introduction Serial measurements of leptin, adiponectin, bile acids, fibro- blast growth factor (FGF)-19, and inflammatory markers were The pathophysiology of obesity is multi-factorial. performed preoperatively and 1 and 6 months after LSG. Adipocytokines released by macrophages and adipocytes play Results The study included ten patients (five females) with a an important role in the pathogenesis of obesity and metabolic mean age of 48.8 years and BMI 40.9 kg/m . At baseline, 90% complications. Changes in weight and fat mass affect of the patients had T2DM, 70% had dyslipidemia, and 90% adiponectin and leptin metabolism. While an increase in had hypertension. Patients lost
Obesity Surgery – Springer Journals
Published: May 31, 2017
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