Early effects of irradiation on laryngeal mucosa in a gastroesophageal reflux model: an experimental study

Early effects of irradiation on laryngeal mucosa in a gastroesophageal reflux model: an... Objective The aim of this study was to evaluate the early histopathological changes of gastroesophageal reflux and irradia- tion on laryngeal mucosa in rats. Study design Animal study. Setting Experimental animal laboratory, tertiary referral center. Subject and method Twenty-four adult female Wistar Albino rats were grouped as: control (n = 6), reflux and irradiation (n = 10), and irradiation (n = 8). Rats were operated to create a reflux model 30 days before irradiation. Ionizing radiation was administered in a single fraction of a 20 Gy to the larynx. Laryngeal tissue samples were taken at the 4th day of irradiation and all specimens underwent histopathological examination. Results Edema and vascular dilation in lamina propria were higher in the reflux and irradiation, and irradiation groups than control group. Inflammation was higher in the reflux and irradiation group than the control group. Inflammation in squamous epithelium was higher in the reflux and irradiation and irradiation groups compared to the control group. Inflammation in the squamous epithelium of the irradiation group was higher than the reflux and irradiation group. In the respiratory tract epithelium, inflammation was higher in the reflux and irradiation group; additionally, a significant loss of cilia was present in the reflux http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Archives of Oto-Rhino-Laryngology Springer Journals

Early effects of irradiation on laryngeal mucosa in a gastroesophageal reflux model: an experimental study

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2018 by Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Medicine & Public Health; Otorhinolaryngology; Neurosurgery; Head and Neck Surgery
ISSN
0937-4477
eISSN
1434-4726
D.O.I.
10.1007/s00405-018-5010-8
Publisher site
See Article on Publisher Site

Abstract

Objective The aim of this study was to evaluate the early histopathological changes of gastroesophageal reflux and irradia- tion on laryngeal mucosa in rats. Study design Animal study. Setting Experimental animal laboratory, tertiary referral center. Subject and method Twenty-four adult female Wistar Albino rats were grouped as: control (n = 6), reflux and irradiation (n = 10), and irradiation (n = 8). Rats were operated to create a reflux model 30 days before irradiation. Ionizing radiation was administered in a single fraction of a 20 Gy to the larynx. Laryngeal tissue samples were taken at the 4th day of irradiation and all specimens underwent histopathological examination. Results Edema and vascular dilation in lamina propria were higher in the reflux and irradiation, and irradiation groups than control group. Inflammation was higher in the reflux and irradiation group than the control group. Inflammation in squamous epithelium was higher in the reflux and irradiation and irradiation groups compared to the control group. Inflammation in the squamous epithelium of the irradiation group was higher than the reflux and irradiation group. In the respiratory tract epithelium, inflammation was higher in the reflux and irradiation group; additionally, a significant loss of cilia was present in the reflux

Journal

European Archives of Oto-Rhino-LaryngologySpringer Journals

Published: Jun 4, 2018

References

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