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Early effects of irradiation on laryngeal mucosa in a gastroesophageal reflux model: an experimental study

Early effects of irradiation on laryngeal mucosa in a gastroesophageal reflux model: an... Objective The aim of this study was to evaluate the early histopathological changes of gastroesophageal reflux and irradia- tion on laryngeal mucosa in rats. Study design Animal study. Setting Experimental animal laboratory, tertiary referral center. Subject and method Twenty-four adult female Wistar Albino rats were grouped as: control (n = 6), reflux and irradiation (n = 10), and irradiation (n = 8). Rats were operated to create a reflux model 30 days before irradiation. Ionizing radiation was administered in a single fraction of a 20 Gy to the larynx. Laryngeal tissue samples were taken at the 4th day of irradiation and all specimens underwent histopathological examination. Results Edema and vascular dilation in lamina propria were higher in the reflux and irradiation, and irradiation groups than control group. Inflammation was higher in the reflux and irradiation group than the control group. Inflammation in squamous epithelium was higher in the reflux and irradiation and irradiation groups compared to the control group. Inflammation in the squamous epithelium of the irradiation group was higher than the reflux and irradiation group. In the respiratory tract epithelium, inflammation was higher in the reflux and irradiation group; additionally, a significant loss of cilia was present in the reflux http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Archives of Oto-Rhino-Laryngology Springer Journals

Early effects of irradiation on laryngeal mucosa in a gastroesophageal reflux model: an experimental study

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Medicine & Public Health; Otorhinolaryngology; Neurosurgery; Head and Neck Surgery
ISSN
0937-4477
eISSN
1434-4726
DOI
10.1007/s00405-018-5010-8
pmid
29869160
Publisher site
See Article on Publisher Site

Abstract

Objective The aim of this study was to evaluate the early histopathological changes of gastroesophageal reflux and irradia- tion on laryngeal mucosa in rats. Study design Animal study. Setting Experimental animal laboratory, tertiary referral center. Subject and method Twenty-four adult female Wistar Albino rats were grouped as: control (n = 6), reflux and irradiation (n = 10), and irradiation (n = 8). Rats were operated to create a reflux model 30 days before irradiation. Ionizing radiation was administered in a single fraction of a 20 Gy to the larynx. Laryngeal tissue samples were taken at the 4th day of irradiation and all specimens underwent histopathological examination. Results Edema and vascular dilation in lamina propria were higher in the reflux and irradiation, and irradiation groups than control group. Inflammation was higher in the reflux and irradiation group than the control group. Inflammation in squamous epithelium was higher in the reflux and irradiation and irradiation groups compared to the control group. Inflammation in the squamous epithelium of the irradiation group was higher than the reflux and irradiation group. In the respiratory tract epithelium, inflammation was higher in the reflux and irradiation group; additionally, a significant loss of cilia was present in the reflux

Journal

European Archives of Oto-Rhino-Laryngology – Springer Journals

Published: Jun 4, 2018

References

  • Gastroesophageal and laryngopharyngeal reflux symptoms correlate with histopathologic inflammation of the upper and lower esophagus
    Wada, T; Sasaki, M; Kataoka, H; Ogasawara, N; Kanematsu, T; Tanida, S; Nojiri, S; Ando, T; Okochi, M; Joh, T
  • Extraesophageal manifestations of gastroesophageal reflux disease
    Vaezi, MF
  • Pathophysiological mechanisms of extraesophageal reflux in otolaryngeal disorders
    Schreiber, S; Garten, D; Sudhoff, H
  • Duodenal contents reflux-induced laryngitis in rats: possible mechanism of enhancement of the causative factors in laryngeal carcinogenesis
    Ling, ZQ; Mukaisho, K; Hidaka, M; Chen, KH; Yamamoto, G; Hattori, T
  • Histological changes of the pharynx and larynx in rats with chronic acid reflux esophagitis
    Shimazu, R; Kusano, K; Kuratomi, Y; Inokuchi, A
  • Establishment of a reflux esophago-laryngitis model in rats
    Asaoka, D; Nagahara, A; Oguro, M
  • Short and long term irradiation effects of on laryngeal mucosa of the rat
    Lidegran, M; Forsgren, S; Dahlqvist, A
  • In vivo and in vitro models of ionizing radiation to the vocal fold
    Saltman, B; Kraus, DH; Szeto, H
  • Experimental model of gastroesophageal reflux in rats
    Gaia Filho, EV; Goldenberg, A; Costa, HO
  • Prophylactic feeding with immune-enhanced diet ameliorates chemoradiation-induced gastrointestinal injury in rats
    Atasoy, BM; Deniz, M; Dane, F
  • Effects of ovariectomy and estrogen replacement therapy on laryngeal tissue: a histopathological experimental animal study
    Tatlıpınar, A; Güneş, P; Özbeyli, D; Çimen, B; Gökçeer, T
  • The pharyngoesophageal dual ambulatory pH probe for evaluation of atypical manifestations of gastroesophageal reflux (GER)
    Wiener, GJ; Koufman, JA; Wu, WC
  • Reflux laryngitis: an update, 2009–2012
    Hawkshaw, MJ; Pebdani, P; Sataloff, RT
  • Association between gastroesophageal reflux and sinusitis, otitis media, and laryngeal malignancy: a systematic review of the evidence
    Weaver, EM
  • The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): A clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury
    Koufman, JA
  • Pharyngo-UES contractile reflux in patients with posterior laryngitis
    Ulualp, SO; Toohill, RJ; Kern, M; Shaker, R
  • Basic clinical radiobilogy
    Joiner, MC
  • Consequential late effects in normal tissues
    Dörr, W; Hendry, JH
  • Do acute mucosal reactions lead to consequential late reactions in patients with head and neck cancer?
    Denham, JW; Peters, LJ; Johansen, J