Dysbiosis in the Gut Bacterial Microbiome of Patients with Uveitis, an Inflammatory Disease of the Eye

Dysbiosis in the Gut Bacterial Microbiome of Patients with Uveitis, an Inflammatory Disease of... Indian J Microbiol https://doi.org/10.1007/s12088-018-0746-9 ORIGINAL RESEARCH ARTICLE Dysbiosis in the Gut Bacterial Microbiome of Patients with Uveitis, an Inflammatory Disease of the Eye 1 1 • • Sama Kalyana Chakravarthy Rajagopalaboopathi Jayasudha Gumpili Sai 1 2 1 3 • • • • Prashanthi Mohammed Hasnat Ali Savitri Sharma Mudit Tyagi Sisinthy Shivaji Received: 4 May 2018 / Accepted: 29 May 2018 Association of Microbiologists of India 2018 Abstract Uveitis (UVT), an inflammatory disease of the (pathogenic) OTUs in UVT microbiomes compared to HC. eye significantly contributes to vision impairment and In addition, decrease in probiotic and antibacterial organ- blindness. Uveitis is associated with systemic infectious isms was observed in UVT compared to HC microbiomes. and autoimmune diseases, but in most cases, the aetiology Heatmap and PCoA plots also indicated significant varia- remains unidentified. Dysbiosis in the gut microbiome has tions in the microbiomes of UVT versus HC. This is the been implicated in autoimmune diseases, inflammatory first study demonstrating dysbiosis in the gut bacterial diseases, cancers and mental disorders. In a mice model of communities of UVT patients in an Indian cohort and autoimmune UVT, it was observed that manipulating the suggests a role of the gut microbiome in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Indian Journal of Microbiology Springer Journals

Dysbiosis in the Gut Bacterial Microbiome of Patients with Uveitis, an Inflammatory Disease of the Eye

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Publisher
Springer India
Copyright
Copyright © 2018 by Association of Microbiologists of India
Subject
Life Sciences; Microbiology; Medical Microbiology
ISSN
0046-8991
eISSN
0973-7715
D.O.I.
10.1007/s12088-018-0746-9
Publisher site
See Article on Publisher Site

Abstract

Indian J Microbiol https://doi.org/10.1007/s12088-018-0746-9 ORIGINAL RESEARCH ARTICLE Dysbiosis in the Gut Bacterial Microbiome of Patients with Uveitis, an Inflammatory Disease of the Eye 1 1 • • Sama Kalyana Chakravarthy Rajagopalaboopathi Jayasudha Gumpili Sai 1 2 1 3 • • • • Prashanthi Mohammed Hasnat Ali Savitri Sharma Mudit Tyagi Sisinthy Shivaji Received: 4 May 2018 / Accepted: 29 May 2018 Association of Microbiologists of India 2018 Abstract Uveitis (UVT), an inflammatory disease of the (pathogenic) OTUs in UVT microbiomes compared to HC. eye significantly contributes to vision impairment and In addition, decrease in probiotic and antibacterial organ- blindness. Uveitis is associated with systemic infectious isms was observed in UVT compared to HC microbiomes. and autoimmune diseases, but in most cases, the aetiology Heatmap and PCoA plots also indicated significant varia- remains unidentified. Dysbiosis in the gut microbiome has tions in the microbiomes of UVT versus HC. This is the been implicated in autoimmune diseases, inflammatory first study demonstrating dysbiosis in the gut bacterial diseases, cancers and mental disorders. In a mice model of communities of UVT patients in an Indian cohort and autoimmune UVT, it was observed that manipulating the suggests a role of the gut microbiome in

Journal

Indian Journal of MicrobiologySpringer Journals

Published: Jun 4, 2018

References

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