Indian J Microbiol https://doi.org/10.1007/s12088-018-0746-9 ORIGINAL RESEARCH ARTICLE Dysbiosis in the Gut Bacterial Microbiome of Patients with Uveitis, an Inﬂammatory Disease of the Eye 1 1 • • Sama Kalyana Chakravarthy Rajagopalaboopathi Jayasudha Gumpili Sai 1 2 1 3 • • • • Prashanthi Mohammed Hasnat Ali Savitri Sharma Mudit Tyagi Sisinthy Shivaji Received: 4 May 2018 / Accepted: 29 May 2018 Association of Microbiologists of India 2018 Abstract Uveitis (UVT), an inﬂammatory disease of the (pathogenic) OTUs in UVT microbiomes compared to HC. eye signiﬁcantly contributes to vision impairment and In addition, decrease in probiotic and antibacterial organ- blindness. Uveitis is associated with systemic infectious isms was observed in UVT compared to HC microbiomes. and autoimmune diseases, but in most cases, the aetiology Heatmap and PCoA plots also indicated signiﬁcant varia- remains unidentiﬁed. Dysbiosis in the gut microbiome has tions in the microbiomes of UVT versus HC. This is the been implicated in autoimmune diseases, inﬂammatory ﬁrst study demonstrating dysbiosis in the gut bacterial diseases, cancers and mental disorders. In a mice model of communities of UVT patients in an Indian cohort and autoimmune UVT, it was observed that manipulating the suggests a role of the gut microbiome in
Indian Journal of Microbiology – Springer Journals
Published: Jun 4, 2018
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