Dynamics of tobacco DNA topoisomerases II in cell cycle regulation: to manage topological constrains during replication, transcription and mitotic chromosome condensation and segregation

Dynamics of tobacco DNA topoisomerases II in cell cycle regulation: to manage topological... Plant Mol Biol (2017) 94:595–607 DOI 10.1007/s11103-017-0626-4 Dynamics of tobacco DNA topoisomerases II in cell cycle regulation: to manage topological constrains during replication, transcription and mitotic chromosome condensation and segregation 1,2 1 1 Badri Nath Singh  · V. Mohan Murali Achary  · Varakumar Panditi  · 1 1 Sudhir K. Sopory  · Malireddy K. Reddy   Received: 22 December 2016 / Accepted: 13 June 2017 / Published online: 20 June 2017 © Springer Science+Business Media B.V. 2017 Abstract to the chromosomes during cell division. The inhibition of Key message The topoisomerase II expression varies as topoisomerase II activity using specific inhibitors revealed a function of cell proliferation. Maximal topoisomerase quite dramatic effect on condensation of chromatin and II expression was tightly coupled to S phase and G2/M chromosome individualization from prophase to metaphase phase via bothtranscriptional and post-transcriptional transition. Partially condensed chromosomes were not regulation. Investigation in meiosis using pollen mother arranged on metaphase plate and chromosomal perturba- cells also revealed that it is not the major component of tions were observed when advance to anaphase, suggest- meiotic chromosomes, itseems to diffuse out once mei- ing the importance of topoisomerase II activity for proper otic chromosomal condensation is completed. chromosome condensation and segregation during mitosis. Abstract Synchronized tobacco BY-2 cell cultures were Contrary, topoisomerase II is http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Plant Molecular Biology Springer Journals

Dynamics of tobacco DNA topoisomerases II in cell cycle regulation: to manage topological constrains during replication, transcription and mitotic chromosome condensation and segregation

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Publisher
Springer Netherlands
Copyright
Copyright © 2017 by Springer Science+Business Media B.V.
Subject
Life Sciences; Plant Sciences; Biochemistry, general; Plant Pathology
ISSN
0167-4412
eISSN
1573-5028
D.O.I.
10.1007/s11103-017-0626-4
Publisher site
See Article on Publisher Site

Abstract

Plant Mol Biol (2017) 94:595–607 DOI 10.1007/s11103-017-0626-4 Dynamics of tobacco DNA topoisomerases II in cell cycle regulation: to manage topological constrains during replication, transcription and mitotic chromosome condensation and segregation 1,2 1 1 Badri Nath Singh  · V. Mohan Murali Achary  · Varakumar Panditi  · 1 1 Sudhir K. Sopory  · Malireddy K. Reddy   Received: 22 December 2016 / Accepted: 13 June 2017 / Published online: 20 June 2017 © Springer Science+Business Media B.V. 2017 Abstract to the chromosomes during cell division. The inhibition of Key message The topoisomerase II expression varies as topoisomerase II activity using specific inhibitors revealed a function of cell proliferation. Maximal topoisomerase quite dramatic effect on condensation of chromatin and II expression was tightly coupled to S phase and G2/M chromosome individualization from prophase to metaphase phase via bothtranscriptional and post-transcriptional transition. Partially condensed chromosomes were not regulation. Investigation in meiosis using pollen mother arranged on metaphase plate and chromosomal perturba- cells also revealed that it is not the major component of tions were observed when advance to anaphase, suggest- meiotic chromosomes, itseems to diffuse out once mei- ing the importance of topoisomerase II activity for proper otic chromosomal condensation is completed. chromosome condensation and segregation during mitosis. Abstract Synchronized tobacco BY-2 cell cultures were Contrary, topoisomerase II is

Journal

Plant Molecular BiologySpringer Journals

Published: Jun 20, 2017

References

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