Duloxetine/escitalopram/venlafaxine

Duloxetine/escitalopram/venlafaxine Reactions 1704, p148 - 2 Jun 2018 Iatrogenic engorgement of the clitoris: case report A 39-year-old woman developed iatrogenic engorgement of the clitoris during treatment with escitalopram, duloxetine and venlafaxine for adjustment disorder with depressed mood [routes not stated]. The woman, who had an adjustment disorder with depressed mood, started receiving treatment with escitalopram 20mg per day. After two days of the therapy, she developed occasional burning, swelling of the clitoris and pinpricks. In a few days, the symptoms turned stronger and regular. An adverse reaction to escitalopram was considered. The woman’s escitalopram was discontinued, and she recovered completely after a week. Thereafter, she was started on duloxetine 30mg per day. However, after two days of the therapy, she experienced the similar symptoms as occurred previously. After a week, duloxetine was stopped with immediate improvement in the symptoms and complete resolution after a few days. At the age of 41 years, she experienced another episode of adjustment disorder with depressed mood and started receiving treatment with venlafaxine 75mg per day. After two days of venlafaxine treatment, she again developed burning, swelling of the clitoris and pinprick as occurred previously. Physical examination demonstrated no erection of the clitoris. Venlafaxine was subsequently stopped. Discontinuation of venlafaxine resulted in complete resolution of the symptoms in a week. Author comment: "[E]scitalopram (20 mg) a day was started. After 2 days, she complained of occasional burning, pinpricks, and swelling of the clitoris. . .Suspecting an adverse reaction,the escitalopram was discontinued. . .trial with 30 mg a day of duloxetine caused the appearance of the same symptoms. . .75 mg a day of venlafaxine was started. Similarly to the previous occasion, after 2 days, the patient complained of burning, pinpricks, and swelling of the clitoris." Raudino F, et al. Iatrogenic Engorgement of the Clitoris Due to Antidepressants: Report of a Case. Journal of Clinical Psychopharmacology 38: 280-281, No. 3, Jun 2018. Available from: URL: http://doi.org/10.1097/JCP.0000000000000881 - Italy 803323722 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Duloxetine/escitalopram/venlafaxine

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46791-1
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p148 - 2 Jun 2018 Iatrogenic engorgement of the clitoris: case report A 39-year-old woman developed iatrogenic engorgement of the clitoris during treatment with escitalopram, duloxetine and venlafaxine for adjustment disorder with depressed mood [routes not stated]. The woman, who had an adjustment disorder with depressed mood, started receiving treatment with escitalopram 20mg per day. After two days of the therapy, she developed occasional burning, swelling of the clitoris and pinpricks. In a few days, the symptoms turned stronger and regular. An adverse reaction to escitalopram was considered. The woman’s escitalopram was discontinued, and she recovered completely after a week. Thereafter, she was started on duloxetine 30mg per day. However, after two days of the therapy, she experienced the similar symptoms as occurred previously. After a week, duloxetine was stopped with immediate improvement in the symptoms and complete resolution after a few days. At the age of 41 years, she experienced another episode of adjustment disorder with depressed mood and started receiving treatment with venlafaxine 75mg per day. After two days of venlafaxine treatment, she again developed burning, swelling of the clitoris and pinprick as occurred previously. Physical examination demonstrated no erection of the clitoris. Venlafaxine was subsequently stopped. Discontinuation of venlafaxine resulted in complete resolution of the symptoms in a week. Author comment: "[E]scitalopram (20 mg) a day was started. After 2 days, she complained of occasional burning, pinpricks, and swelling of the clitoris. . .Suspecting an adverse reaction,the escitalopram was discontinued. . .trial with 30 mg a day of duloxetine caused the appearance of the same symptoms. . .75 mg a day of venlafaxine was started. Similarly to the previous occasion, after 2 days, the patient complained of burning, pinpricks, and swelling of the clitoris." Raudino F, et al. Iatrogenic Engorgement of the Clitoris Due to Antidepressants: Report of a Case. Journal of Clinical Psychopharmacology 38: 280-281, No. 3, Jun 2018. Available from: URL: http://doi.org/10.1097/JCP.0000000000000881 - Italy 803323722 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References

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