Eur J Clin Pharmacol (2017) 73:1197–1198 DOI 10.1007/s00228-017-2290-7 LETTER TO THE EDITOR Duloxetine and gingival bleeding: a case-report and reviews of the French and World PharmacoVigilance Databases and literature 1 1 2 3 4 Céline Gicquel & Florence Moulis & Chouki Chenaf & Aurore Gouraud & Milou Drici & 1 1 1 Emmanuelle Bondon-Guitton & François Montastruc & Jean-Louis Montastruc Received: 18 May 2017 /Accepted: 13 June 2017 /Published online: 22 June 2017 Springer-Verlag GmbH Germany 2017 Duloxetine is a serotonin-noradrenaline reuptake inhibitor spontaneous GB, associated with dry mouth, observed (SNRI) used for major depression, anxiety disorder, diabetic throughout the whole day and during 2 months until pain, and fibromyalgia . Common adverse drug reactions withdrawal. GB disappeared after discontinuing (ADRs) are nausea, headache, dry mouth, somnolence, and duloxetine. There was no previous medical history. dizziness . Association between bleeding and antidepres- The patient also received omeprazole (20 mg/day), para- sants is discussed. Serotonin reuptake inhibitors (SRIs) or cetamol (2 g/day), and codeine (120 mg/day). Biological SNRIs can inhibit serotonin-induced platelet aggregation am- tests were normal. Medical examination failed to find plification, decreasing platelet aggregability and prolonging any buccal lesion. Causality assessment was Blikely^ bleeding time [3–5]. We describe
European Journal of Clinical Pharmacology – Springer Journals
Published: Jun 22, 2017
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