Dual Receptor Targeting Cell Penetrating Peptide Modified Liposome for Glioma and Breast Cancer Postoperative Recurrence Therapy

Dual Receptor Targeting Cell Penetrating Peptide Modified Liposome for Glioma and Breast Cancer... Pharm Res (2018) 35: 130 https://doi.org/10.1007/s11095-018-2399-0 RESEARCH PAPER Dual Receptor Targeting Cell Penetrating Peptide Modified Liposome for Glioma and Breast Cancer Postoperative Recurrence Therapy 1 1 1 1 1 1 2 1 Yue Qiu & Qianwen Yu & Yayuan Liu & Jiajing Tang & Xuhui Wang & Zhengze Lu & Zhuping Xu & Qin He Received: 14 December 2017 /Accepted: 31 March 2018 /Published online: 26 April 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018 ABSTRACT group was 39.51 ± 4.02% when PBS group was set as Purpose Cell penetrating peptides (CPPs) were widely used 100%. C6 and 4 T1 bioluminescent tumor resected as motifs for drug delivery to tumor. In former study, an RGD model were established, then effectiveness of different reverse sequence dGR was used to develop active-targeting PTX-loaded preparations were evaluated on these two liposome R8dGR-Lip, which showed well penetrating ability models. PTX-R8dGR-Lip could obviously inhibit tumor and treatment efficiency on glioma model. However, recur- recurrence, prolong survival rate and reduce tumor tis- rence after tumor resection caused by post-operative residual sue invasion. cancer cells was a huge obstacle in tumor treatment. In con- Conclusion PTX-R8dGR-Lip could reduce post-operative sideration of the effective http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmaceutical Research Springer Journals

Dual Receptor Targeting Cell Penetrating Peptide Modified Liposome for Glioma and Breast Cancer Postoperative Recurrence Therapy

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Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Biomedicine; Pharmacology/Toxicology; Pharmacy; Biochemistry, general; Medical Law; Biomedical Engineering
ISSN
0724-8741
eISSN
1573-904X
D.O.I.
10.1007/s11095-018-2399-0
Publisher site
See Article on Publisher Site

Abstract

Pharm Res (2018) 35: 130 https://doi.org/10.1007/s11095-018-2399-0 RESEARCH PAPER Dual Receptor Targeting Cell Penetrating Peptide Modified Liposome for Glioma and Breast Cancer Postoperative Recurrence Therapy 1 1 1 1 1 1 2 1 Yue Qiu & Qianwen Yu & Yayuan Liu & Jiajing Tang & Xuhui Wang & Zhengze Lu & Zhuping Xu & Qin He Received: 14 December 2017 /Accepted: 31 March 2018 /Published online: 26 April 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018 ABSTRACT group was 39.51 ± 4.02% when PBS group was set as Purpose Cell penetrating peptides (CPPs) were widely used 100%. C6 and 4 T1 bioluminescent tumor resected as motifs for drug delivery to tumor. In former study, an RGD model were established, then effectiveness of different reverse sequence dGR was used to develop active-targeting PTX-loaded preparations were evaluated on these two liposome R8dGR-Lip, which showed well penetrating ability models. PTX-R8dGR-Lip could obviously inhibit tumor and treatment efficiency on glioma model. However, recur- recurrence, prolong survival rate and reduce tumor tis- rence after tumor resection caused by post-operative residual sue invasion. cancer cells was a huge obstacle in tumor treatment. In con- Conclusion PTX-R8dGR-Lip could reduce post-operative sideration of the effective

Journal

Pharmaceutical ResearchSpringer Journals

Published: Apr 26, 2018

References

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