Pharm Res (2018) 35: 130 https://doi.org/10.1007/s11095-018-2399-0 RESEARCH PAPER Dual Receptor Targeting Cell Penetrating Peptide Modified Liposome for Glioma and Breast Cancer Postoperative Recurrence Therapy 1 1 1 1 1 1 2 1 Yue Qiu & Qianwen Yu & Yayuan Liu & Jiajing Tang & Xuhui Wang & Zhengze Lu & Zhuping Xu & Qin He Received: 14 December 2017 /Accepted: 31 March 2018 /Published online: 26 April 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018 ABSTRACT group was 39.51 ± 4.02% when PBS group was set as Purpose Cell penetrating peptides (CPPs) were widely used 100%. C6 and 4 T1 bioluminescent tumor resected as motifs for drug delivery to tumor. In former study, an RGD model were established, then effectiveness of different reverse sequence dGR was used to develop active-targeting PTX-loaded preparations were evaluated on these two liposome R8dGR-Lip, which showed well penetrating ability models. PTX-R8dGR-Lip could obviously inhibit tumor and treatment efficiency on glioma model. However, recur- recurrence, prolong survival rate and reduce tumor tis- rence after tumor resection caused by post-operative residual sue invasion. cancer cells was a huge obstacle in tumor treatment. In con- Conclusion PTX-R8dGR-Lip could reduce post-operative sideration of the effective
Pharmaceutical Research – Springer Journals
Published: Apr 26, 2018
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