EDITORIAL Dual isotope and multidetector camera: The best choices for a speciﬁc end-point a a,b Roberta Assante, MD, and Wanda Acampa, MD, PhD Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy Institute of Biostructure and Bioimaging, National Council of Research, Naples, Italy Received Apr 12, 2016; accepted Apr 12, 2016 doi:10.1007/s12350-016-0520-5 of viable but sympathetically denervated myocardial See related article, pp. 1361–1369 areas, deﬁned as trigger zone. In fact, myocardial 123I- MIBG uptake was not only reduced in the central infarct zone involved by the severe reduction of perfusion tra- cer uptake, but also in adjacent still viable regions as Assessment of myocardial infarct tissue has shown well as in areas with acute and chronic ischemia to play an important role in risk-stratify patients for reﬂecting better the total extent of injured myocardium. adverse cardiac events. Infarct tissue may show con- These regions with impaired innervation may be viable siderable spatial heterogeneity due to the presence of and hypersensitive to catecholamine, resulting in necrotic areas that are intermingled with bundles of increased automaticity and enhanced triggering and it viable cardiomyocytes. Myocardial necrosis is primarily has been demonstrated that the presence of trigger zone located in the middle
Journal of Nuclear Cardiology – Springer Journals
Published: May 19, 2016
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