Dual activation of Toll-like receptors 7 and 9 impairs the efficacy of antitumor vaccines in murine models of metastatic breast cancer

Dual activation of Toll-like receptors 7 and 9 impairs the efficacy of antitumor vaccines in... J Cancer Res Clin Oncol (2017) 143:1713–1732 DOI 10.1007/s00432-017-2421-7 ORIGINAL ARTICLE – CANCER RESEARCH Dual activation of Toll‑like receptors 7 and 9 impairs the efficacy of antitumor vaccines in murine models of metastatic breast cancer 1 1,2 3 1 Mariela A. Moreno Ayala · María Florencia Gottardo · María Soledad Gori · Alejandro Javier Nicola Candia · 1,2 4,5 1 6 2,6 Carla Caruso · Andrea De Laurentiis · Mercedes Imsen · Slobodanka Klein · Elisa Bal de Kier Joffé · 3,7 8,9 1,2 1 Gabriela Salamone · Maria G. Castro · Adriana Seilicovich · Marianela Candolfi Received: 30 April 2016 / Accepted: 8 April 2017 / Published online: 21 April 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract simultaneously activated. Blockade of nitric oxide synthase Purpose Since combination of Toll-like receptor (TLR) (NOS) and indoleamine-pyrrole-2,3-dioxygenase (IDO) ligands could boost antitumor immunity, we evaluated the improved the activation of CpG-DCs. When we evaluated efficacy of dendritic cell (DC) vaccines upon dual activa - the effect of combined activation of TLR9 and TLR7 in tion of TLR9 and TLR7 in breast cancer models. human DCs, we found that R848 induced robust DC activa- Methods DCs were generated from mouse bone marrow http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Cancer Research and Clinical Oncology Springer Journals
Loading next page...
 
/lp/springer_journal/dual-activation-of-toll-like-receptors-7-and-9-impairs-the-efficacy-of-K4MLyQFx8z
Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Medicine & Public Health; Oncology; Cancer Research; Internal Medicine; Hematology
ISSN
0171-5216
eISSN
1432-1335
D.O.I.
10.1007/s00432-017-2421-7
Publisher site
See Article on Publisher Site

Abstract

J Cancer Res Clin Oncol (2017) 143:1713–1732 DOI 10.1007/s00432-017-2421-7 ORIGINAL ARTICLE – CANCER RESEARCH Dual activation of Toll‑like receptors 7 and 9 impairs the efficacy of antitumor vaccines in murine models of metastatic breast cancer 1 1,2 3 1 Mariela A. Moreno Ayala · María Florencia Gottardo · María Soledad Gori · Alejandro Javier Nicola Candia · 1,2 4,5 1 6 2,6 Carla Caruso · Andrea De Laurentiis · Mercedes Imsen · Slobodanka Klein · Elisa Bal de Kier Joffé · 3,7 8,9 1,2 1 Gabriela Salamone · Maria G. Castro · Adriana Seilicovich · Marianela Candolfi Received: 30 April 2016 / Accepted: 8 April 2017 / Published online: 21 April 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract simultaneously activated. Blockade of nitric oxide synthase Purpose Since combination of Toll-like receptor (TLR) (NOS) and indoleamine-pyrrole-2,3-dioxygenase (IDO) ligands could boost antitumor immunity, we evaluated the improved the activation of CpG-DCs. When we evaluated efficacy of dendritic cell (DC) vaccines upon dual activa - the effect of combined activation of TLR9 and TLR7 in tion of TLR9 and TLR7 in breast cancer models. human DCs, we found that R848 induced robust DC activa- Methods DCs were generated from mouse bone marrow

Journal

Journal of Cancer Research and Clinical OncologySpringer Journals

Published: Apr 21, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off