Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Dual activation of Toll-like receptors 7 and 9 impairs the efficacy of antitumor vaccines in murine models of metastatic breast cancer

Dual activation of Toll-like receptors 7 and 9 impairs the efficacy of antitumor vaccines in... J Cancer Res Clin Oncol (2017) 143:1713–1732 DOI 10.1007/s00432-017-2421-7 ORIGINAL ARTICLE – CANCER RESEARCH Dual activation of Toll‑like receptors 7 and 9 impairs the efficacy of antitumor vaccines in murine models of metastatic breast cancer 1 1,2 3 1 Mariela A. Moreno Ayala · María Florencia Gottardo · María Soledad Gori · Alejandro Javier Nicola Candia · 1,2 4,5 1 6 2,6 Carla Caruso · Andrea De Laurentiis · Mercedes Imsen · Slobodanka Klein · Elisa Bal de Kier Joffé · 3,7 8,9 1,2 1 Gabriela Salamone · Maria G. Castro · Adriana Seilicovich · Marianela Candolfi Received: 30 April 2016 / Accepted: 8 April 2017 / Published online: 21 April 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract simultaneously activated. Blockade of nitric oxide synthase Purpose Since combination of Toll-like receptor (TLR) (NOS) and indoleamine-pyrrole-2,3-dioxygenase (IDO) ligands could boost antitumor immunity, we evaluated the improved the activation of CpG-DCs. When we evaluated efficacy of dendritic cell (DC) vaccines upon dual activa - the effect of combined activation of TLR9 and TLR7 in tion of TLR9 and TLR7 in breast cancer models. human DCs, we found that R848 induced robust DC activa- Methods DCs were generated from mouse bone marrow http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Cancer Research and Clinical Oncology Springer Journals

Loading next page...
 
/lp/springer_journal/dual-activation-of-toll-like-receptors-7-and-9-impairs-the-efficacy-of-K4MLyQFx8z

References (118)

Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Medicine & Public Health; Oncology; Cancer Research; Internal Medicine; Hematology
ISSN
0171-5216
eISSN
1432-1335
DOI
10.1007/s00432-017-2421-7
pmid
28432455
Publisher site
See Article on Publisher Site

Abstract

J Cancer Res Clin Oncol (2017) 143:1713–1732 DOI 10.1007/s00432-017-2421-7 ORIGINAL ARTICLE – CANCER RESEARCH Dual activation of Toll‑like receptors 7 and 9 impairs the efficacy of antitumor vaccines in murine models of metastatic breast cancer 1 1,2 3 1 Mariela A. Moreno Ayala · María Florencia Gottardo · María Soledad Gori · Alejandro Javier Nicola Candia · 1,2 4,5 1 6 2,6 Carla Caruso · Andrea De Laurentiis · Mercedes Imsen · Slobodanka Klein · Elisa Bal de Kier Joffé · 3,7 8,9 1,2 1 Gabriela Salamone · Maria G. Castro · Adriana Seilicovich · Marianela Candolfi Received: 30 April 2016 / Accepted: 8 April 2017 / Published online: 21 April 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract simultaneously activated. Blockade of nitric oxide synthase Purpose Since combination of Toll-like receptor (TLR) (NOS) and indoleamine-pyrrole-2,3-dioxygenase (IDO) ligands could boost antitumor immunity, we evaluated the improved the activation of CpG-DCs. When we evaluated efficacy of dendritic cell (DC) vaccines upon dual activa - the effect of combined activation of TLR9 and TLR7 in tion of TLR9 and TLR7 in breast cancer models. human DCs, we found that R848 induced robust DC activa- Methods DCs were generated from mouse bone marrow

Journal

Journal of Cancer Research and Clinical OncologySpringer Journals

Published: Apr 21, 2017

There are no references for this article.