J Cancer Res Clin Oncol (2017) 143:1713–1732 DOI 10.1007/s00432-017-2421-7 ORIGINAL ARTICLE – CANCER RESEARCH Dual activation of Toll‑like receptors 7 and 9 impairs the efficacy of antitumor vaccines in murine models of metastatic breast cancer 1 1,2 3 1 Mariela A. Moreno Ayala · María Florencia Gottardo · María Soledad Gori · Alejandro Javier Nicola Candia · 1,2 4,5 1 6 2,6 Carla Caruso · Andrea De Laurentiis · Mercedes Imsen · Slobodanka Klein · Elisa Bal de Kier Joffé · 3,7 8,9 1,2 1 Gabriela Salamone · Maria G. Castro · Adriana Seilicovich · Marianela Candolfi Received: 30 April 2016 / Accepted: 8 April 2017 / Published online: 21 April 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract simultaneously activated. Blockade of nitric oxide synthase Purpose Since combination of Toll-like receptor (TLR) (NOS) and indoleamine-pyrrole-2,3-dioxygenase (IDO) ligands could boost antitumor immunity, we evaluated the improved the activation of CpG-DCs. When we evaluated efficacy of dendritic cell (DC) vaccines upon dual activa - the effect of combined activation of TLR9 and TLR7 in tion of TLR9 and TLR7 in breast cancer models. human DCs, we found that R848 induced robust DC activa- Methods DCs were generated from mouse bone marrow
Journal of Cancer Research and Clinical Oncology – Springer Journals
Published: Apr 21, 2017
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