Drosophila Rhodopsin 7 can partially replace the structural role of Rhodopsin 1, but not its physiological function

Drosophila Rhodopsin 7 can partially replace the structural role of Rhodopsin 1, but not its... Rhodopsin 7 (Rh7), a new invertebrate Rhodopsin gene, was discovered in the genome of Drosophila melanogaster in 2000 and thought to encode for a functional Rhodopsin protein. Indeed, Rh7 exhibits most hallmarks of the known Rhodopsins, except for the G-protein-activating QAKK motif in the third cytoplasmic loop that is absent in Rh7. Here, we show that Rh7 can partially substitute Rh1 in the outer receptor cells (R1–6) for rhabdomere maintenance, but that it cannot activate the phototransduction cascade in these cells. This speaks against a role of Rh7 as photopigment in R1–6, but does not exclude that it works in the inner photoreceptor cells. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Comparative Physiology A Springer Journals

Drosophila Rhodopsin 7 can partially replace the structural role of Rhodopsin 1, but not its physiological function

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Publisher
Springer Journals
Copyright
Copyright © 2017 by The Author(s)
Subject
Life Sciences; Animal Physiology; Neurosciences; Zoology
ISSN
0340-7594
eISSN
1432-1351
D.O.I.
10.1007/s00359-017-1182-8
Publisher site
See Article on Publisher Site

Abstract

Rhodopsin 7 (Rh7), a new invertebrate Rhodopsin gene, was discovered in the genome of Drosophila melanogaster in 2000 and thought to encode for a functional Rhodopsin protein. Indeed, Rh7 exhibits most hallmarks of the known Rhodopsins, except for the G-protein-activating QAKK motif in the third cytoplasmic loop that is absent in Rh7. Here, we show that Rh7 can partially substitute Rh1 in the outer receptor cells (R1–6) for rhabdomere maintenance, but that it cannot activate the phototransduction cascade in these cells. This speaks against a role of Rh7 as photopigment in R1–6, but does not exclude that it works in the inner photoreceptor cells.

Journal

Journal of Comparative Physiology ASpringer Journals

Published: May 12, 2017

References

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