The bithorax complex (BX-C) genes have a regulatory region containing nine independent para-segment-specific enhancers. Inactivation of the enhancers is a result of Pc-mediated repression, which leads to the appearance of active and repressed domains. Active domains are supposed to be separated from the repressed domains by insulators on the domain boundaries. Three insulators were found in the BX-C by the ability to block enhancers in transgenic model systems. Here, we have demonstrated that one of these three well studied insulators, Fab-7, is able to protect the yellow gene transcription from the most powerful Polycomb-dependent silencer from the bxd regulatory domain of the Ultrabithorax gene (Ubx). The barrier activity requires a region containing GAF-binding sites. Interestingly, the silencer used in the model system (1.5 kb PRE from the regulatory region of Ubx) recruits a transgenic construct with a frequency of up to 47% into genomic regions that completely repress the yellow gene expression.
Russian Journal of Genetics – Springer Journals
Published: Mar 28, 2012
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