Drivers and Barriers to Drug Discovery: Insights from a Cross-sectional Survey

Drivers and Barriers to Drug Discovery: Insights from a Cross-sectional Survey Purpose Motivated by stagnant new drug approval rates, this study explores the drivers and barriers to drug discovery to extract policy-relevant advice. Methods As part of a doctoral dissertation, an online survey was administered to drug discovery experts between July and November 2017. Respondents came from patents, startup managers/founders, conference speakers, consultants, and LinkedIn profiles, contingent on finding respondent emails from a web search. Respondents ranked drivers and barriers to drug discovery and judged R&D and drug approval trends. Results Pooling responses based on frequency of mentions, indicate that respondents deem Bskilled R&D scientists^, BR&D investments^,and Bgood R&D management^ as the top three drivers of drug discovery. The Bdepth^ of specialized knowledge is mentioned more than the Bdiversity^ of knowledge available to the discovery team. Likewise, Bcomplex clinical trials^, Bcompanies pursuing the same drug targets^,and Bdesigning drug substances with a single or narrow therapeutic benefits^ are top ranked barriers to drug discovery. The majority view is that R&D spending has been stagnant for the past decade. New drug approval trend is judged to be improving in the past 5 years. Ninety percent of respondents believe their responses are gener- alizable to other therapeutic areas, indicating instrument’s validity in capturing http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Pharmaceutical Innovation Springer Journals

Drivers and Barriers to Drug Discovery: Insights from a Cross-sectional Survey

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Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Biomedicine; Pharmacology/Toxicology; Industrial and Production Engineering; Biotechnology; Biochemical Engineering
ISSN
1872-5120
eISSN
1939-8042
D.O.I.
10.1007/s12247-018-9331-3
Publisher site
See Article on Publisher Site

Abstract

Purpose Motivated by stagnant new drug approval rates, this study explores the drivers and barriers to drug discovery to extract policy-relevant advice. Methods As part of a doctoral dissertation, an online survey was administered to drug discovery experts between July and November 2017. Respondents came from patents, startup managers/founders, conference speakers, consultants, and LinkedIn profiles, contingent on finding respondent emails from a web search. Respondents ranked drivers and barriers to drug discovery and judged R&D and drug approval trends. Results Pooling responses based on frequency of mentions, indicate that respondents deem Bskilled R&D scientists^, BR&D investments^,and Bgood R&D management^ as the top three drivers of drug discovery. The Bdepth^ of specialized knowledge is mentioned more than the Bdiversity^ of knowledge available to the discovery team. Likewise, Bcomplex clinical trials^, Bcompanies pursuing the same drug targets^,and Bdesigning drug substances with a single or narrow therapeutic benefits^ are top ranked barriers to drug discovery. The majority view is that R&D spending has been stagnant for the past decade. New drug approval trend is judged to be improving in the past 5 years. Ninety percent of respondents believe their responses are gener- alizable to other therapeutic areas, indicating instrument’s validity in capturing

Journal

Journal of Pharmaceutical InnovationSpringer Journals

Published: Jun 4, 2018

References

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