Purpose Motivated by stagnant new drug approval rates, this study explores the drivers and barriers to drug discovery to extract policy-relevant advice. Methods As part of a doctoral dissertation, an online survey was administered to drug discovery experts between July and November 2017. Respondents came from patents, startup managers/founders, conference speakers, consultants, and LinkedIn profiles, contingent on finding respondent emails from a web search. Respondents ranked drivers and barriers to drug discovery and judged R&D and drug approval trends. Results Pooling responses based on frequency of mentions, indicate that respondents deem Bskilled R&D scientists^, BR&D investments^,and Bgood R&D management^ as the top three drivers of drug discovery. The Bdepth^ of specialized knowledge is mentioned more than the Bdiversity^ of knowledge available to the discovery team. Likewise, Bcomplex clinical trials^, Bcompanies pursuing the same drug targets^,and Bdesigning drug substances with a single or narrow therapeutic benefits^ are top ranked barriers to drug discovery. The majority view is that R&D spending has been stagnant for the past decade. New drug approval trend is judged to be improving in the past 5 years. Ninety percent of respondents believe their responses are gener- alizable to other therapeutic areas, indicating instrument’s validity in capturing
Journal of Pharmaceutical Innovation – Springer Journals
Published: Jun 4, 2018
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