Doxorubicin Reactions 1680, p123 - 2 Dec 2017 Moderate impairment of cardiac contractibility: case report In a single institution long-term prospective study, a patient [age and sex not stated] was described, who developed moderate impairment of cardiac contractibility during treatment with doxorubicin [duration of treatment to reaction onset not stated]. The patient, who was newly diagnosed with Hodgkin lymphoma, started receiving chemotherapy with ABVD regimen that included IV doxorubicin 25 mg/m for days 1 and 15. Subsequently, the patient developed moderate impairment of cardiac contractibility. The patient was treated with carvedilol and a favourable outcome was achieved. Author comment: "The cumulative dose of doxorubicin raises concern on cardiac contractility in the long term, but if [radiotherapy] is avoided the potentiation of this late effect is reduced." "Other incidental complications were . . .moderate impairment of cardiac contractibility (1 patient treated with carvedilol with favorable outcome)". Zubizarreta PA, et al. Children and Adolescent Hodgkin Lymphoma in Argentina: Long-term Results After Combined ABVD and Restricted Radiotherapy. Journal of Pediatric Hematology/Oncology 39: 602-608, No. 8, Nov 2017. Available from: URL: - Argentina 803285521 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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