Arch Gynecol Obstet (2017) 296:543–549 DOI 10.1007/s00404-017-4444-3 GY NEC O LOG I C O NCO L OG Y Down-regulation of PARP1 by miR-891b sensitizes human breast cancer cells to alkylating chemotherapeutic drugs 1,2 3 2 2 2 • • • • • Shujian Xu Cui Zhao Zhongming Jia Xilong Wang Yong Han Zhenlin Yang Received: 2 January 2017 / Accepted: 22 June 2017 / Published online: 28 June 2017 Springer-Verlag GmbH Germany 2017 Abstract Conclusion MiR-891b increases the sensitivity of the Purpose Breast cancer is the most common invasive type breast cancer cells (HCC1806) to the cytotoxic effects of of cancer among women. Role of different microRNAs the chemotherapeutic agent MNNG by suppressing the (miRNAs) and poly(ADP-ribose) polymerases (PARPs) in expression of PARP1. breast cancer has been well established. This study aimed to explore the effects of miR-891b on sensitizing breast Keywords Breast cancer MicroRNA-181b PARP1 cancer cells to alkylating chemotherapeutic drugs through Alkylating chemotherapeutic agent MNNG PARPs. Methods The expression of miR-891b and PARP1 in human breast cancer cells HCC1806 was overexpressed by Introduction transfection with their mimics or expressing vector. Then, the transfected cells were exposed to 40 lM N-methyl-N- Breast cancer is considered
Archives of Gynecology and Obstetrics – Springer Journals
Published: Jun 28, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera