Down-regulation of PARP1 by miR-891b sensitizes human breast cancer cells to alkylating chemotherapeutic drugs

Down-regulation of PARP1 by miR-891b sensitizes human breast cancer cells to alkylating... Arch Gynecol Obstet (2017) 296:543–549 DOI 10.1007/s00404-017-4444-3 GY NEC O LOG I C O NCO L OG Y Down-regulation of PARP1 by miR-891b sensitizes human breast cancer cells to alkylating chemotherapeutic drugs 1,2 3 2 2 2 • • • • • Shujian Xu Cui Zhao Zhongming Jia Xilong Wang Yong Han Zhenlin Yang Received: 2 January 2017 / Accepted: 22 June 2017 / Published online: 28 June 2017 Springer-Verlag GmbH Germany 2017 Abstract Conclusion MiR-891b increases the sensitivity of the Purpose Breast cancer is the most common invasive type breast cancer cells (HCC1806) to the cytotoxic effects of of cancer among women. Role of different microRNAs the chemotherapeutic agent MNNG by suppressing the (miRNAs) and poly(ADP-ribose) polymerases (PARPs) in expression of PARP1. breast cancer has been well established. This study aimed to explore the effects of miR-891b on sensitizing breast Keywords Breast cancer  MicroRNA-181b  PARP1 cancer cells to alkylating chemotherapeutic drugs through Alkylating chemotherapeutic agent  MNNG PARPs. Methods The expression of miR-891b and PARP1 in human breast cancer cells HCC1806 was overexpressed by Introduction transfection with their mimics or expressing vector. Then, the transfected cells were exposed to 40 lM N-methyl-N- Breast cancer is considered http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Gynecology and Obstetrics Springer Journals

Down-regulation of PARP1 by miR-891b sensitizes human breast cancer cells to alkylating chemotherapeutic drugs

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag GmbH Germany
Subject
Medicine & Public Health; Gynecology; Obstetrics/Perinatology/Midwifery; Endocrinology; Human Genetics
ISSN
0932-0067
eISSN
1432-0711
D.O.I.
10.1007/s00404-017-4444-3
Publisher site
See Article on Publisher Site

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