Eur J Clin Pharmacol (2017) 73:1071–1081 DOI 10.1007/s00228-017-2221-7 CLINICAL TRIAL Dose-related effect of statins in patients with endovascular coiling or microsurgical clipping for aneurysmal subarachnoid hemorrhage: updated study-level meta-analysis 1 1 1 2 3 Kyu-Sun Choi & Jae Min Kim & Hyeong-Joong Yi & Seon-Heui Lee & Taeho Lim & 4 4 1 Wonhee Kim & Youngsuk Cho & Jin-Hwan Cheong Received: 8 December 2016 /Accepted: 17 February 2017 /Published online: 14 March 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract 0.80; 95% CI, 0.58–1.11; P = 0.18). In observational studies, Purpose Weaimedtoquantitativelyassesstheeffectsof statin use was not associated with any reduction in DINDs, short-term statin use on delayed ischemic neurologic deficits poor outcome, or mortality. Meta-analysis of RCTs indicated a (DINDs) and clinical outcomes in patients with aneurysmal significant reduction in DINDs and mortality in patients with subarachnoid hemorrhage (SAH) through a meta-analysis of high-dose statin use (RR, 0.63; 95% CI, 0.42–0.95; P =0.03; 2 2 the available evidence. I = 0%; and RR, 0.36; 95% CI, 0.15–0.86; P =0.02; I =0%, Methods We searched the electronic databases up to April 8, respectively). 2016 to retrieve relevant studies comparing the outcomes be- Conclusion The present meta-analysis suggests that statin use tween
European Journal of Clinical Pharmacology – Springer Journals
Published: Mar 14, 2017
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