Dose-dependent responses of pigs infected with foot-and-mouth disease virus O/JPN/2010 by the intranasal and intraoral routes

Dose-dependent responses of pigs infected with foot-and-mouth disease virus O/JPN/2010 by the... Foot-and-mouth disease virus (FMDV) infection was successfully initiated in pigs by intraoral inoculation of both 10 6 and 10 3 TCID 50 of FMDV O/JPN/2010 isolated from the 2010 epidemic in Japan. By intranasal inoculation, infection was established in pigs with 10 6 TCID 50 of the isolate, but not with 10 3 TCID 50 of the isolate. In the pigs inoculated with 10 6 TCID 50 of the isolate, viruses and viral RNAs were obtained earlier from the pigs inoculated by the intraoral route than from the pigs inoculated by the intranasal route. These results support the theory that primary infection of a pig herd is more likely to occur by ingestion than by inhalation and that the oral cavity is likely to be a major entry route for FMDV in naturally exposed pigs. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Dose-dependent responses of pigs infected with foot-and-mouth disease virus O/JPN/2010 by the intranasal and intraoral routes

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Publisher
Springer Vienna
Copyright
Copyright © 2015 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-014-2239-4
Publisher site
See Article on Publisher Site

References

  • Molecular epidemiology of foot-and-mouth disease virus
    Knowles, NJ; Samuel, AR
  • The foot-and-mouth disease epidemic in Japan, 2010
    Muroga, N; Hayama, Y; Yamamoto, T; Kurogi, A; Tsuda, T; Tsutsui, T
  • Direct contact transmission of three different foot-and-mouth disease virus strains in swine demonstrates important strain-specific differences
    Pacheco, JM; Tucker, M; Hartwig, E; Bishop, E; Arzt, J; Rodriguez, LL
  • Foot-and-mouth disease: a review of intranasal infection of cattle, sheep and pigs
    Sellers, R; Gloster, J

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