Eur J Nutr (2018) 57:155–166 https://doi.org/10.1007/s00394-016-1304-z ORIGINAL CONTRIBUTION Donkey milk consumption exerts anti‑inflammatory properties by normalizing antimicrobial peptides levels in Paneth’s cells in a model of ileitis in mice 1,2 1 1 2 Sophie Yvon · Maïwenn Olier · Mathilde Leveque · Gwenaëlle Jard · 2 2 2 1,2 Helene Tormo · Djamila Ali Haimoud‑Lekhal · Magali Peter · Hélène Eutamène Received: 13 April 2016 / Accepted: 23 August 2016 / Published online: 31 August 2016 © Springer-Verlag Berlin Heidelberg 2016 Abstract intestinal length, (2) a significant increase in MDS, MD and Purpose In this study, we showed the beneficial effects of LCN-2, (3) a reduction in both α-defensin mRNA expression donkey milk (DM) on inflammatory damages, endogenous and lysozyme levels in Paneth’s cells reflected by a decrease antimicrobial peptides levels and fecal microbiota profile in in lysozyme activity in feces, and (4) a global change in rela- a mice model of Crohn’s disease. Nowadays, new strategies tive abundance of targeted microbial communities. DM treat- of microbiome manipulations are on the light involving spe- ment significantly reduced almost of all these ileitis dam - cific diets to induce and/or to maintain clinical remission. ages, whereas heated DM has no
European Journal of Nutrition – Springer Journals
Published: Aug 31, 2016
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