Donepezil

Donepezil Reactions 1704, p144 - 2 Jun 2018 Postprandial hypotension: case report An 80-year-old woman developed postprandial hypotension while receiving donepezil [indication, route and dosage not stated]. The woman had a remarkable history of hypertension, osteopenia, moderate dementia, hyperlipidaemia along with multiple syncopal episodes. The syncopal episodes started 3 years prior to the current presentation. During 2014 2017, she had multiple emergency department visits with the same clinical presentations. At some occasions, she was found unconscious on a chair. Her family witnessed two syncopal episodes during meals at the dining table. The episodes were manifested as slumping forward, becoming unresponsive for approx. 30 seconds and then returned to normal after a few minutes. Her all relevant investigations were unremarkable. She then presented to a geriatric clinic (current presentation) where her aforementioned symptoms were suspected due to her donepezil therapy [duration of treatment to reaction onset not stated]. Subsequently, the woman’s donepezil and BP medications were discontinued and she was recommended with optimum hydration and compressive stocking [outcome not stated]. Author comment: "She had multiple ED visits throughout 2014–2017 describing similar picture of patient being found unconscious on a chair, confused with no signs of urinary or fecal incontinence, denying chest pain, shortness of breath, abdominal pain, dysuria, fever, nausea, vomiting.. . .Donepezil was discontinued as thought to be contributing to these events in one of the visits." Cruz Madrid KY. "Think out of the box difficulties in diagnosing postprandial hypotension in the elderly". Journal of the American Geriatrics Society 66 (Suppl. 2): S175-S176 (plus poster) abstr. C8, Jan 2018. Available from: URL: http:// doi.org/10.1111/jgs.15376 [abstract] - USA 803323361 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Donepezil

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46787-2
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p144 - 2 Jun 2018 Postprandial hypotension: case report An 80-year-old woman developed postprandial hypotension while receiving donepezil [indication, route and dosage not stated]. The woman had a remarkable history of hypertension, osteopenia, moderate dementia, hyperlipidaemia along with multiple syncopal episodes. The syncopal episodes started 3 years prior to the current presentation. During 2014 2017, she had multiple emergency department visits with the same clinical presentations. At some occasions, she was found unconscious on a chair. Her family witnessed two syncopal episodes during meals at the dining table. The episodes were manifested as slumping forward, becoming unresponsive for approx. 30 seconds and then returned to normal after a few minutes. Her all relevant investigations were unremarkable. She then presented to a geriatric clinic (current presentation) where her aforementioned symptoms were suspected due to her donepezil therapy [duration of treatment to reaction onset not stated]. Subsequently, the woman’s donepezil and BP medications were discontinued and she was recommended with optimum hydration and compressive stocking [outcome not stated]. Author comment: "She had multiple ED visits throughout 2014–2017 describing similar picture of patient being found unconscious on a chair, confused with no signs of urinary or fecal incontinence, denying chest pain, shortness of breath, abdominal pain, dysuria, fever, nausea, vomiting.. . .Donepezil was discontinued as thought to be contributing to these events in one of the visits." Cruz Madrid KY. "Think out of the box difficulties in diagnosing postprandial hypotension in the elderly". Journal of the American Geriatrics Society 66 (Suppl. 2): S175-S176 (plus poster) abstr. C8, Jan 2018. Available from: URL: http:// doi.org/10.1111/jgs.15376 [abstract] - USA 803323361 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

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