J Hematopathol (2017) 10:141–143 https://doi.org/10.1007/s12308-017-0307-x LETTER TO THE EDITOR Does the mutational status affect the bone marrow morphological findings in patients with classical Philadelphia-negative myeloproliferative neoplasms? 1 2 3 3 L. Medina-Vega & L. Hernández-Nieto & H. Álvarez-Argüelles & E. Salido & J. M. Raya Received: 18 October 2017 /Accepted: 19 October 2017 /Published online: 8 November 2017 Springer-Verlag GmbH Germany 2017 The histopathological findings that can be observed in the risk of myelofibrotic transformation, and a higher degree of bone marrow biopsy of patients with Philadelphia-negative fibrosis in patients with PMF is associated with a worse prog- chronic myeloproliferative neoplasms have become relevant, nosis . as evidenced by the most current classification of this group of In recent years, molecular alterations described in chronic Philadelphia-negative myeloproliferative neoplasms, mainly entities, published last year by the WHO . These morpho- logical characteristics are considered of crucial interest to es- JAK2 V617F, calreticulin (CALR), and MPL, have gained tablish their diagnosis, together with the inclusion of the mo- great diagnostic and prognostic interest [3, 4]. In addition, it lecular advances that explain the clonality of the disease and is known that there may be a correlation between a genetic or peripheral
Journal of Hematopathology – Springer Journals
Published: Nov 8, 2017
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