J Endocrinol Invest (2018) 41:439–445 https://doi.org/10.1007/s40618-017-0764-1 ORIGINAL ARTICLE Does endogenous GLP‑1 affect resting energy expenditure and fuel selection in overweight and obese adults? 1 1 2 3 1 4 E. Poggiogalle · L. M. Donini · C. Chiesa · L. Pacifico · A. Lenzi · S. Perna · 4 5 4 M. Faliva · M. Naso · M. Rondanelli Received: 15 August 2017 / Accepted: 19 September 2017 / Published online: 3 October 2017 © Italian Society of Endocrinology (SIE) 2017 Abstract associated with fasting GLP-1 levels (p = 0.98) after adjust- Purpose To investigate the association between fasting ment for age, sex, fat-free mass (FFM), and fat mass (FM). glucagon-like peptide 1 (GLP-1) levels and resting energy Similarly, no association was observed between RQ and expenditure (REE), and respiratory quotient (RQ) in over- GLP-1 levels (p = 0.95), after adjustment for age, sex, and weight and obese adults. body fat. Method Study participants were enrolled at the Dietetic Conclusion In adults subjects with increased adiposity and Metabolic Unit, University of Pavia, Italy. Inclusion fasting, GLP-1 levels do not seem to play a role in the regu- criteria were age ≥ 25 and ≤ 45 years, and body mass lation of energy metabolism and in fuel selection. index (BMI) ≥ 25 and ≤ 35 kg/m . Diabetic subjects were excluded.
Journal of Endocrinological Investigation – Springer Journals
Published: Oct 3, 2017
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