Docosahexaenoic-acid/eicosapentaenoic-acid/phosphatidylserine Reactions 1680, p122 - 2 Dec 2017 Docosahexaenoic-acid/ eicosapentaenoic-acid/ phosphatidylserine Worsening of Tourette’s syndrome: case report A 14-year-old boy developed worsening of Tourette’s syndrome following treatment with eicosapentaenoic acid/ docosahexaenoic acid/phosphatidylserine [Vayarin] [route not stated]. The boy, at the age of eight years, received dextroamphetamine and amphetamine for one day. Subsequently, he developed a tic, which stopped after discontinuation of dextroamphetamine and amphetamine. However, he continued having attention difficulties and mumbled tetragrams. He had a regular obsession about movies and continuously chewed non-food objects. He was started on eicosapentaenoic acid/docosahexaenoic acid/ phosphatidylserine twice a day. After few hours, he began spitting uncontrollably onto the floor. The spitting continued to such an extent that it covered the floor with a saliva puddle. Despite cessation of eicosapentaenoic acid/ docosahexaenoic acid/phosphatidylserine, the compulsive expectoration was unstoppable. Physical examination revealed occasional tic of face and right shoulder and frequent mumbling of inarticulate tetragrams. Gait examination revealed adventitious movements along with dystonic posturing of both upper limbs on heel walking. Clock drawing test, animal fluency test and Go-No-Go test results were normal. Eicosapentaenoic acid/docosahexaenoic acid/ phosphatidylserine may enhance concentration and his attention deficit/hyperactivity disorder (ADHD) but worsen any compulsive obsessive symptoms of Tourette’s syndrome such as spitting [outcome not stated]. Author comment: "[Eicosapentaenoic acid/docohexaenoic acid/phosphatidylserine]may worsen any obsessive compulsive symptoms of [Tourette’s syndrome]." Burero Z, et al. Eicosapentaenoic acid-, phosphatidylserine-, and docohexaenoic acid (Vayarin)-induced spitting in Tourette's syndrome. CNS Spectrums 22: 106, No. 1, 2017. Available from: URL: S1092852916000900 [abstract] - Pakistan 803284989 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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