Docetaxel/cisplatin/fluorouracil

Docetaxel/cisplatin/fluorouracil Reactions 1704, p142 - 2 Jun 2018 Non-occlusive mesenteric ischaemia: 2 case reports In a case series, two men were described, of whom, a 79-year-old developed non-occlusive mesenteric ischaemia (NOMI) during treatment with docetaxel for local recurrence of prostate cancer and a 74-year-old man developed NOMI during treatment with docetaxel, fluorouracil [5-fluorouracil] and cisplatin for oropharyngeal cancer [dosages, routes and outcomes not stated]. Case 1: The man, who had local recurrence of prostate cancer, started receiving docetaxel. During the first week of docetaxel initiation, he presented with the complaint of abdominal pain. Abdominal computed tomography(CT) showed mesenteric ischemia and intestinal emphysema. Thereafter, a diagnosis of NOMI was made. Therefore, he underwent an emergency operation. A laparotomy revealed a mottled necrosis of gall bladder, small intestine, recto sigmoid and ascending, transverse and descending colon. Therefore, all these were excised. Case 2: The man, who had oropharyngeal cancer, started receiving combination chemotherapy, which included docetaxel, cisplatin and 5-FU. One week after the initiation of chemotherapy, he presented with fever and abdominal pain. An abdominal contrast CT examination revealed mesenteric ischemia, which was confirmed as NOMI. Therefore, an emergency surgery was performed on the same day. The entire ileum appeared discoloured with mottling, and found to be necrotic. Hence, it was excised. He was discharged from the hospital and his post-surgery course was good. Author comment: "In general, mesenteric ischaemia after administration of anticancer drugs is rare, and only a few cases have been reported." Wada T, et al. Two Cases of Non-Occlusive Mesenteric Ischemia That Developed after Chemotherapy. Gan to Kagaku Ryoho 44: 1396-1398, No. 12, Nov 2017. Available from: URL: https://www.ncbi.nlm.nih.gov/pubmed/29394646 [Japanese; summarised from an english abstract] - Japan 803322718 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Docetaxel/cisplatin/fluorouracil

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46785-2
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p142 - 2 Jun 2018 Non-occlusive mesenteric ischaemia: 2 case reports In a case series, two men were described, of whom, a 79-year-old developed non-occlusive mesenteric ischaemia (NOMI) during treatment with docetaxel for local recurrence of prostate cancer and a 74-year-old man developed NOMI during treatment with docetaxel, fluorouracil [5-fluorouracil] and cisplatin for oropharyngeal cancer [dosages, routes and outcomes not stated]. Case 1: The man, who had local recurrence of prostate cancer, started receiving docetaxel. During the first week of docetaxel initiation, he presented with the complaint of abdominal pain. Abdominal computed tomography(CT) showed mesenteric ischemia and intestinal emphysema. Thereafter, a diagnosis of NOMI was made. Therefore, he underwent an emergency operation. A laparotomy revealed a mottled necrosis of gall bladder, small intestine, recto sigmoid and ascending, transverse and descending colon. Therefore, all these were excised. Case 2: The man, who had oropharyngeal cancer, started receiving combination chemotherapy, which included docetaxel, cisplatin and 5-FU. One week after the initiation of chemotherapy, he presented with fever and abdominal pain. An abdominal contrast CT examination revealed mesenteric ischemia, which was confirmed as NOMI. Therefore, an emergency surgery was performed on the same day. The entire ileum appeared discoloured with mottling, and found to be necrotic. Hence, it was excised. He was discharged from the hospital and his post-surgery course was good. Author comment: "In general, mesenteric ischaemia after administration of anticancer drugs is rare, and only a few cases have been reported." Wada T, et al. Two Cases of Non-Occlusive Mesenteric Ischemia That Developed after Chemotherapy. Gan to Kagaku Ryoho 44: 1396-1398, No. 12, Nov 2017. Available from: URL: https://www.ncbi.nlm.nih.gov/pubmed/29394646 [Japanese; summarised from an english abstract] - Japan 803322718 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References

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