Purpose To study the role of individual semen parameters on the offspring birth weight and body mass index (BMI) from a population of men evaluated in an assisted reproduction technology (ART) clinic compared to fertile controls. Methods We performed a retrospective study using a cohort with fertile, age-matched controls of men evaluated with semen analysis at the University of Utah Andrology Clinic from 1996 to 2011 and Intermountain Healthcare from 2002 to 2011. We use the offspring from both our sub-fertile cohort and controls using the Utah Population Database. The two main outcomes of interest were offspring birth weight and adolescent BMI. Results The offspring of men with impaired sperm parameters had significantly lower birth weight compared to fertile control offspring. Low-concentration offspring weighed 158 g less (95% CI − 278~− 38; p = 0.01), low total count weighed 172 g less (95% CI − 294~− 51; p = 0.005), and low total motility weighed 155 g less (95% CI − 241~− 69; p <0.001)compared tothose of the controls. When we controlled for the use of ART within the sub-fertile group, we found that there was a significant trend of increasing birth weight across levels of total motile count
Journal of Assisted Reproduction and Genetics – Springer Journals
Published: Mar 17, 2018
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