J Mater Sci: Mater Med (2018) 29:18 DOI 10.1007/s10856-017-6021-5 BIOMATERIALS SYNTHESIS AND CHARACTERIZATION Rapid Communication 1,2 2 3 ● ● ● Lukas Gritsch Christopher Lovell Wolfgang H. Goldmann Aldo R. Boccaccini Received: 22 September 2017 / Accepted: 6 December 2017 / Published online: 16 January 2018 © The Author(s) 2018. This article is an open access publication Abstract Biodegradable and bioresorbable polyesters Graphical abstract (BBPEs) are a widespread class of aliphatic polymers with a plethora of applications in the medical ﬁeld. Some reports speculate that these polymers have intrinsic antibacterial activity as a consequence of their acidic degradation by- products. The release of organic acids as a result of the hydrolytic degradation of BBPEs in vivo and the resulting pH drop could be an effective inhibitor of the growth of pathogens in the local environment adjacent to BBPE-based devices. However, there is no clear and conclusive evidence in the literature concerning the antibacterial activity of BBPE to support or refute this hypothesis. In this commu- nication we address this point through an assessment of the antibacterial properties of six well-established commercially available BBPEs. Agar diffusion assays and optical density measurements at 600 nm were performed on all the polymer
Journal of Materials Science: Materials in Medicine – Springer Journals
Published: Jan 16, 2018
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