Gastric Cancer (2017) 20:784–792 DOI 10.1007/s10120-017-0697-6 ORIGINAL ARTICLE DNA diagnosis of peritoneal ﬂuid cytology test by CDO1 promoter DNA hypermethylation in gastric cancer 1 1 1 1 • • • • Hideki Ushiku Keishi Yamashita Akira Ema Naoko Minatani 1 1 1 1 • • • • Mariko Kikuchi Ken Kojo Keigo Yokoi Toshimichi Tanaka 1 1 1 1 • • • • Nobuyuki Nishizawa Satoru Ishii Kei Hosoda Hiromitsu Moriya 1 1 1 1 • • • • Hiroaki Mieno Natsuya Katada Shiro Kikuchi Hiroshi Katoh Masahiko Watanabe Received: 11 December 2016 / Accepted: 20 January 2017 / Published online: 27 February 2017 The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2017 Abstract detect minimal residual disease of the peritoneum in GC Background Minimal residual disease of the peritoneum is clinics as a novel DNA marker. challenging for early cancer detection in gastric cancer (GC). Utility of PCR ampliﬁcation of cancer-derived DNA Keywords Cysteine dioxygenase type 1 (CDO1) DNA has been considered feasible due to its molecular stability, methylation Gastric cancer Peritoneal ﬂuid cytology however such markers have never been available in GC test DNA diagnosis clinics. We recently discovered cancer-speciﬁc
Gastric Cancer – Springer Journals
Published: Feb 27, 2017
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